Hypertrophic Cardiomyopathy

Description

This extensively updated edition provides a comprehensive review of hypertrophic cardiomyopathy, the most common genetic disorder of the heart characterized by dysfunctional contractility at the sarcomere level. The disease produces abnormal and oftentimes focal hypertrophy on a macroscopic level that further impairs cardiac performance and may lead to life-threatening arrhythmias. This edition provides a practical approach, establishing evidence-based best practice for all scenarios. Hypertrophic Cardiomyopathy provides readers with key points and critical clinical pearls to assist them in managing patients. New chapters have been included on managing hypertension, sleep apnea, coronary artery disease, structural and congenital disease, nutrition and pharmacotherapies. All aspects of treatment are covered – medications, pacemakers and defibrillators, and invasive septal reduction therapy (both surgical myectomy and alcohol septal ablation) – in addition to genetics, family screening, lifestyle concerns, and athletic screening. The practical approach has been reinforced with an expanded emphasis on creating a Center of Excellence, how to facilitate the multi-disciplinary approach, and on case-based reviews and discussions, with each chapter ending with a post-test. This book is an essential text for cardiology professionals from trainee to board-certified physician, and includes important information for interventional cardiologists, cardiac surgeons, cardiac imagers, critical care physicians, sports medicine physicians, genetic counsellors, and electrophysiologists. Front Matter ....Pages i-xx Hypertrophic Cardiomyopathy: The Past, the Present, and the Future (Eugene Braunwald)....Pages 1-8 Natural History of Hypertrophic Cardiomyopathy (Arnon Adler, Qin Li, Lynne Williams, Harry Rakowski)....Pages 9-21 Pathology and Pathophysiology (Atsushi Sakamoto, Kazuyuki Yahagi, Maria Romero, Renu Virmani)....Pages 23-39 Approach to Diagnosis: Echocardiography (Beevash Ray, Matthew W. Martinez)....Pages 41-58 Cardiac MRI in Diagnosis and Management (Daniele Massera, Jonathan Kahan, Juan Gaztanaga, Mario J. Garcia)....Pages 59-81 Genetics of HCM and Role of Genetic Testing (Christopher Semsarian, Jodie Ingles)....Pages 83-91 Assessment of Heart Failure: Invasive and Noninvasive Methods (Yuichi J. Shimada, Aaron L. Baggish, Michael A. Fifer)....Pages 93-106 Assessment of Syncope (Nickolaos Michelakis, Todd J. Cohen)....Pages 107-120 Pediatric Diagnosis and Management (Steven D. Colan, Christa Miliaresis)....Pages 121-144 Sudden Cardiac Death Risk Assessment (Perry Elliott, Katy E. Bockstall, Matthew A. Cain, Mohammed Majid Akhtar, Mark S. Link)....Pages 145-155 Youth and Athletic Screening: Rationale, Methods, and Outcome (David S. Owens, Sanjay Sharma)....Pages 157-168 Lifestyle Modification: Diet, Exercise, Sports, and Other Issues (David S. Owens)....Pages 169-182 Diet, Nutrition, and Managing Obesity (Lisa Salberg, Aslan Turer)....Pages 183-188 Family Screening: Who, When, and How (Michelle Michels)....Pages 189-198 Medical Therapy: From Beta-Blockers to Disopyramide (Keith Mankowitz, Mark V. Sherrid)....Pages 199-219 Hypertension and Hypertrophic Cardiomyopathy (Andrew Wang)....Pages 221-230 Diagnosing and Managing Pulmonary and Right-Sided Heart Disease: Pulmonary Hypertension, Right Ventricular Outflow Pathology, and Sleep Apnea (M. Fuad Jan, A. Jamil Tajik)....Pages 231-248 Epiphenomena in Hypertrophic Cardiomyopathy: Acquired von Willebrand Syndrome (Joseph L. Blackshear)....Pages 249-262 Epicardial and Microvascular Ischemia: Implications, Diagnosis, and Management (George S. Hanzel)....Pages 263-273 Indications and Outcome of PPM and ICD Placement (Joseph J. Germano, Joshua R. DeLeon, Daniel R. Zakhary, Jason T. Jacobson)....Pages 275-290 Management of Arrhythmia: Medications, Electrophysiology Studies, and Ablation (Daniel R. Zakhary, Joseph J. Germano)....Pages 291-303 Indications for and Individualization of Septal Reduction Therapy (Dmitriy N. Feldman, John S. Douglas Jr., Srihari S. Naidu)....Pages 305-323 Surgical Myectomy and Associated Procedures: Techniques and Outcomes (Daniel G. Swistel, Heidi Schubmehl, Sandhya K. Balaram)....Pages 325-343 Alcohol Septal Ablation: Technique and Outcome (Paul Sorajja, Sherif Nagueh)....Pages 345-359 Managing the High-Risk Patient: Critical Care, TAVR, MitraClip, Pressors, and Cardiac Assist Devices (Timothy C. Wong, Eugene C. DePasquale, Arnold S. Baas)....Pages 361-372 End-Stage Diastolic and Systolic Heart Failure: Evaluation and Timing of Heart Transplantation (Eric D. Popjes, Anjali Tiku Owens)....Pages 373-382 Novel Medical Therapeutics for Hypertrophic Cardiomyopathy (Stephen B. Heitner)....Pages 383-387 Approach to the Initial and Follow-Up Visits (Paolo Spirito, Camillo Autore)....Pages 389-406 Evaluation and Management of Hypertrophic Cardiomyopathic Patients Through Noncardiac Surgery and Pregnancy (Nadia B. Hensley, Theodore P. Abraham)....Pages 407-417 Building a Hypertrophic Cardiomyopathy Center of Excellence (B. Robinson Williams III, Lisa Salberg)....Pages 419-427 Longitudinal Case-Based Presentations in HCM (Abdul Moiz Hafiz, Jonathan Elias, Kanika Mody, Jenna Kahn, Sahil Khera, Ankur Kalra et al.)....Pages 429-468 Back Matter ....Pages 469-479