ENGLISH

Antibody Expression and Production

By Mohamed Al-Rubeai (eds.) , Thomas Jostock (auth.)

Book information

Publisher
Springer Netherlands
Year
2011
ISBN
9400712561, 9789400712560
DOI
10.1007/978-94-007-1257-7
ISSN
1389-6946
Google Books ID
pRzrKqVa7YsC
Language
english
Format
PDF
Filesize
6 MB (6602512 bytes)
Series
Cell Engineering 7
Edition
1
Pages
346\356
Orientation
yes
Scanned
no
Time added
2011-08-31 04:54:40
Biomedicine general

Description

Engineered antibodies currently represent over 30% of biopharmaceuticals in clinical trials and their total worldwide sales continue to increase significantly. The importance of antibody applications is reflected in their increasing clinical and industrial applications as well as in the progression of established and emerging production strategies. This volume provides detailed coverage of the generation, optimization, characterization, production and applications of antibody. It provides the necessary theoretical background and description of methods for the expression of antibody in microbial and animal cell cultures and in transgenic animals and plants. There is a strong focus on those issues related to the production of intrabodies, bispecific antibody and antibody fragments and also to novel applications in cancer immunotherapy.

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