Retinal Pigment Epithelium in Health and Disease

Description

This book provides a contemporary resource on one of the major players in retinal diseases – the Retinal Pigment Epithelium (RPE). Throughout the book, the physiological and the pathological function of the RPE are covered on equal terms, to help readers to understand the RPE as a whole. Moreover, the development of RPE in diagnostics and therapy are covered, as well as some practical knowledge about RPE experimental models. Retinal Pigment Epithelium in Health and Disease highlights new findings of RPE research and includes the state-of-the-art knowledge of each RPE topic presented. This important feature sets this book apart from other publications, with the chapters following a design which leads from the general to the specific, to give a precise collection of the facts known. The chapters are written by well-known experts that are currently active in the field as consultants, basic scientists, and group leaders, providing expert guidance on the current aspects and future outlooks of this topic. Front Matter ....Pages i-xi Front Matter ....Pages 1-1 RPE Histopathology and Morphometry (Eszter Szalai, John M. Nickerson, Hans E. Grossniklaus)....Pages 3-17 RPE Polarity and Barrier Function (Lawrence J. Rizzolo)....Pages 19-45 RPE Phagocytosis (Claudia Müller, Silvia C. Finnemann)....Pages 47-63 Ion Channels of the Retinal Pigment Epithelium (Nadine Reichhart, Olaf Strauß)....Pages 65-84 RPE and the Vascular Endothelial Growth Factor (Alexa Karina Klettner)....Pages 85-99 The RPE Cell and the Immune System (Barbara Detrick, John J. Hooks)....Pages 101-114 Front Matter ....Pages 115-115 The RPE in Myopia Development (Yan Zhang, Christine F. Wildsoet)....Pages 117-138 Retinal Pigment Epithelium in Proliferative Disorders (Willem A. Dik, Jeroen Bastiaans, Jan C. van Meurs)....Pages 139-160 Retinal Pigment Epithelium in Age-Related Macular Degeneration (Kai Kaarniranta, Antero Salminen, Anu Kauppinen)....Pages 161-171 Retinal Pigment Epithelium in Health and Disease: Maturation, Aging and Age-Related Macular Degeneration (Thomas Ach, Ioana-Sandra Tarau, Christine A. Curcio)....Pages 173-183 Sex Related Differences in Retinal Pigment Epithelium and Retinal Disease (Gloriane Schnabolk, Elisabeth Obert, Bärbel Rohrer)....Pages 185-201 Front Matter ....Pages 203-203 RPE in SD-OCT (Andrea Hassenstein, Carsten Grohmann)....Pages 205-232 RPE Autofluorescence (Stefan Dithmar, Nil Celik)....Pages 233-245 Front Matter ....Pages 247-247 RPE and Stem Cell Therapy (Heli Skottman)....Pages 249-263 RPE and Gene Therapy (Knut Stieger, Birgit Lorenz)....Pages 265-279 RPE and Laser (Claus von der Burchard, Johann Roider)....Pages 281-292 Front Matter ....Pages 293-293 Retinal Pigment Epithelium Cell Culture (Alexa Karina Klettner)....Pages 295-305 Retinal Pigment Epithelium Organ Culture (Yoko Miura)....Pages 307-324 Animal Models of Diseases of the Retinal Pigment Epithelium (Erica L. Fletcher, Ursula Greferath, Philipp Guennel, Mario Huynh, Quan D. Findlay, Andrew I. Jobling et al.)....Pages 325-347 Back Matter ....Pages 349-357