Growth Factors and their Receptors in Cancer Metastasis

Description

about the involvement of signaling Transforming growth factor in tumor development and metastasis. plays a central role in the signaling network that controls morphogenesis, 2. THE BASICS OF growth and cell differentiation in SIGNALING multicellular organisms. The different members of this pleiotropic family of 2. 1. receptor signaling growth and differentiation factors seem to The family of growth factors regulate many processes in human disease consists of more than thirty members in and, in particular, tumor development. humans alone (15, 16). They cluster in Our understanding of how two major groups, the group composed of initiated signals are mediated has both the bone morphogenetic proteins increased dramatically in the last fifteen (BMP) and growth and differentiation years. Firstly, the prototype of factors (GDFs), and the group formed by this still constantly growing family, was the Activins, and Nodals. The two identified and cloned (1). Secondly, the groups differ in their use of receptors for family receptors were transmembrane receptors and the identified by expression cloning from subsequent activation of the mammalian tissue culture (2-7). Thirdly, transcriptional mediators (for recent genetic screens in Drosophila reviews see (13, 14, 17)). The Role of Leukemia Inhibitory Factor in Cancer and Cancer Metastasis....Pages 1-25 Interleukin-2 and its Receptors in Human Solid Tumours: Immunobiology and Clinical Significance....Pages 27-50 Interleukin-8 and Angiogenesis....Pages 51-65 The Role of Interleukein-11 in the Formation of Bone Metastases....Pages 67-78 Therapeutic Potential of Adenovirus Mediated Interleukin-12 Gene Therapy for Prostate Cancer....Pages 79-91 Fibroblast Growth Factors and Their Receptors in Metastases of Prostate and Other Urological Cancers....Pages 93-106 Insulin-like Growth Factor Axis Elements in Breast Cancer Progression....Pages 107-166 The Role of Platelet Derived Growth Factor (PDGF) and Its Receptors in Cancer and Metastasis....Pages 167-186 TGFβ Receptor Signaling in Cancer and Metastasis....Pages 187-222 VEGF-C/VEGFRS and Cancer Metastasis....Pages 223-239 HGF-c-Met Receptor Pathway in Tumor Invasion-metastasis and Potential Cancer Treatment With NK4....Pages 241-276 Growth Factor Receptors and Cell Adhesion Complexes in Cytoskeletal Assembly/Anchorage....Pages 277-290