Asymmetric synthesis of drugs and natural products

Description

"This book focuses on different techniques of asymmetric synthesis of important compounds, such as drugs and natural products. It gives insightful information on recent asymmetric synthesis by Inorganic, Organic and Enzymatic combinations."--Provided by publisher. Abstract: "This book focuses on different techniques of asymmetric synthesis of important compounds, such as drugs and natural products. It gives insightful information on recent asymmetric synthesis by Inorganic, Organic and Enzymatic combinations."--Provided by publisher Content: Cover Half Title Title Page Copyright Page Table of Contents Preface Contributors Chapter 1: Basic Stereochemical Approaches to Natural Products and Drugs 1.1 Basic Concept of Chirality 1.2 Meso Compounds 1.3 Tautomerism and Valance Tautomerism 1.4 Conformation 1.5 Fischer Projection and Absolute Configuration 1.6 Chiral Resolution 1.6.1 Crystal Picking 1.6.2 Chemical Separation 1.6.3 Biochemical Separation 1.6.4 Chromatographic Separation 1.7 Application of Enantiomers in Drugs and Natural Products Problems Answers References Chapter 2: Diastereoselective Addition of Organometallic Reagents to Chiral Carbonyl Compounds2.1 Introduction 2.2 Models for Asymmetric Carbonyl Compound Addition 2.3 Models for 1,2-Asymmetric Carbonyl Addition 2.4 Models for 1,3-Asymmetric Carbonyl Addition 2.5 Addition of Achiral Reagents 2.6 Addition of Aldehyde 2.6.1 Aldehydes Containing a-Oxygen Substituent 2.6.2 Aldehydes Containing a-Nitrogen Substituent 2.6.3 Aldehydes Containing Other Heteroatoms in a-Position 2.7 Addition of Chiral Ketones 2.7.1 Acyclic a-Chiral Ketones 2.7.2 Acyclic Chiral Ketones Containing Oxygen in a-Position2.7.3 Acyclic Chiral Ketones Containing Nitrogen in a-Position 2.7.4 Acyclic Chiral Ketones Containing Other Heteroatoms in a-Position 2.7.5 Cyclic Ketones 2.8 Conclusion References Chapter 3: Enantiomerically Pure Compounds by Enantioselective Synthetic Chiral Metal Complexes 3.1 Introduction 3.2 History 3.2.1 Mechanism of Dirhodium(II)-Catalyzed Cyclopropanation Reactions 3.2.2 Types of Dirhodium(II)-Carbenoid Intermediates 3.2.3 Modes of Interaction between the Dirhodium(II) Complex and the Carbene 3.2.4 Approach of the Alkene3.3 Modifications in the Dirhodium(II) Frame 3.3.1 Electronic Modifications 3.3.2 Steric Modifications 3.4 Dirhodium(II) Carboxylate Complexes 3.4.1 Conformations in Dirhodium(II) Carboxylate Complexes 3.4.2 Dirhodium(II) Catalysts Derived from Proline-Based Ligands 3.5 Dirhodium(II) Catalysts Derived from Chiral N-Protected Amino Acid Ligands 3.5.1 Homoleptic Complexes 3.5.2 Heteroleptic Complexes 3.5.3 Dirhodium(II) Catalysts Derived from Substituted Cyclopropane Carboxylate Ligands 3.6 Dirhodium(II) Carboxamidates 3.6.1 Homoleptic Complexes 3.6.2 Heteroleptic Complexes3.7 Effects of Axial Ligands on Enantioselectivity 3.8 Conclusion References Chapter 4: Chirality Organization of Peptides and Ï#x80 -Conjugated Polyanilines 4.1 Introduction 4.2 Chirality Organization of Peptides 4.2.1 Chirality Organization of Peptides by Using Organic Molecular Scaffold 4.2.2 Chirality Organization of Peptides by Using Organometallic Molecular Scaffold 4.3 Synthesis of Optically Active Polyanilines 4.3.1 Polymerization of Anilines in the Presence of a Chiral Acid 4.3.2 Doping of Emeraldine Bases with a Chiral Acid