ENGLISH

Fibrostenotic Inflammatory Bowel Disease

By Florian Rieder

Book information

Publisher
Springer International Publishing
Year
2018
ISBN
978-3-319-90577-8;978-3-319-90578-5
Language
english
Format
PDF
Filesize
14 MB (14826117 bytes)
Edition
1st ed.
Pages
XII, 397\395
Time added
2019-01-12 07:45:50
Medicine & Public Health; Gastroenterology; Pathol

Description

This book provides a comprehensive account of the pathogenesis and treatment of intestinal fibrosis, covering both the clinical and molecular aspects of the disease. It begins by describing the epidemiology and genetics of fibrostenosing IBD in Crohn’s disease and Ulcerative colitis as well as the epigenetics and cellular and molecular mechanisms of the disease. Readers will obtain an in-depth overview of the disease from biomarkers and histology to surgical intervention, imaging and current and future drug therapies. Medical management of fibrosis, endoscopy and imaging as well as surgical approaches are all discussed. Through the links to videos contained in the book, the reader will become familiar with interventional procedures such as endoscopic balloon dilation and surgical techniques for stricturing IBD, such as resection and strictureplasties. This is an indispensable volume for anyone working on fibrostenotic IBD, such as gastroenterologists, internists, radiologists, colorectal surgeons, pathologists and researchers. It has been written by a team of top experts from North America, Asia and Europe. Front Matter ....Pages i-xii Fibrostenotic Inflammatory Bowel Disease: A Cinderella Story (Florian Rieder)....Pages 1-4 Epidemiology and Natural History of Fibrostenosing Inflammatory Bowel Disease (Wee Khoon Ng, Siew C. Ng)....Pages 5-12 Genetic Influences on the Development of Fibrosis in Inflammatory Bowel Disease (Bram Verstockt, Sare Verstockt, Isabelle Cleynen)....Pages 13-38 Epigenetic Regulation of Intestinal Fibrosis (Chao Li, John F. Kuemmerle)....Pages 39-58 Cytokine and Anti-Cytokine Agents as Future Therapeutics for Fibrostenosing IBD (Noam Jacob, Stephan R. Targan, David Q. Shih)....Pages 59-75 Inflammation-Independent Mechanisms of Intestinal Fibrosis: The Role of the Extracellular Matrix (Debby Laukens)....Pages 77-95 Fat and Fibrosis (Ren Mao, J. Calvin Coffey)....Pages 97-109 Environmental Factors and Their Influence on Intestinal Fibrosis (Claudio Bernardazzi, Fernando Castro, Heitor S. de Souza)....Pages 111-126 Animal Models and Sources of Mesenchymal Cells in Intestinal Fibrosis (Dominik Bettenworth)....Pages 127-145 Fibrosis in Ulcerative Colitis (Fernando Magro, Tatiana António)....Pages 147-157 Histopathology of Intestinal Fibrosis (Ilyssa O. Gordon)....Pages 159-171 Clinical, Cellular and Serologic Biomarkers of Intestinal Fibrosis (Antonio Di Sabatino, Paolo Giuffrida)....Pages 173-181 Imaging in Intestinal Fibrosis. What Is State of the Art? (Jordi Rimola)....Pages 183-192 The Future of Intestinal Fibrosis Imaging (Ryan W. Stidham, Mahmoud Al-Hawary)....Pages 193-208 Medical Therapy in Stricturing Inflammatory Bowel Diseases (Damien Soudan, Yoram Bouhnik)....Pages 209-223 Endoscopic Therapy of Intestinal Strictures: What Is State of the Art? (Talat Bessissow, Gert Van Assche)....Pages 225-232 Resectional Surgery for Intestinal Strictures: What Is State of the Art? (Karin A. T. G. M. Wasmann, Christianne J. Buskens, Pieter J. Tanis, Willem A. Bemelman)....Pages 233-252 Management of Ileal Pouch Strictures and Anal Stricturing Disease: A Clinical Challenge (Jean H. Ashburn, Tracy L. Hull)....Pages 253-266 Stricturing Crohn’s Disease: Strictureplasty (Gabriele Bislenghi, Andre D’Hoore)....Pages 267-293 Challenges of Translation of Anti-Fibrotic Therapies into Clinical Practice in IBD (Gerhard Rogler)....Pages 295-305 What Distinguishes Mechanisms of Fistula and Stricture Formation (Michael Scharl)....Pages 307-317 The Pathogenesis of Intraabdominal Adhesions: Similarities and Differences to Luminal Fibrosis (Edward Macarak, Joel Rosenbloom)....Pages 319-346 Anti-Fibrotic Therapies from Other Organs: What the Gut Can Learn from the Liver, Skin, Lung and Heart (Calen A. Steiner, Peter D. R. Higgins)....Pages 347-385 Back Matter ....Pages 387-397

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