Advances in Heart Valve Biomechanics: Valvular Physiology, Mechanobiology, and Bioengineering

Description

This book covers the latest research development in heart valve biomechanics and bioengineering, with an emphasis on novel experimentation, computational simulation, and applications in heart valve bioengineering. The most current research accomplishments are covered in detail, including novel concepts in valvular viscoelasticity, fibril/molecular mechanisms of tissue behavior, fibril kinematics-based constitutive models, mechano-interaction of valvular interstitial and endothelial cells, biomechanical behavior of acellular valves and tissue engineered valves, novel bioreactor designs, biomechanics of transcatheter valves, and 3D heart valve printing. This is an ideal book for biomedical engineers, biomechanics, surgeons, clinicians, business managers in the biomedical industry, graduate and undergraduate students studying biomedical engineering, and medical students. Front Matter ....Pages i-xxv Front Matter ....Pages 1-1 Biological Mechanics of the Heart Valve Interstitial Cell (Alex Khang, Rachel M. Buchanan, Salma Ayoub, Bruno V. Rego, Chung-Hao Lee, Michael S. Sacks)....Pages 3-36 Endothelial Mechanotransduction (James N. Warnock)....Pages 37-58 The Role of Proteoglycans and Glycosaminoglycans in Heart Valve Biomechanics (Varun K. Krishnamurthy, K. Jane Grande-Allen)....Pages 59-79 On the Unique Functional Elasticity and Collagen Fiber Kinematics of Heart Valve Leaflets (Jun Liao, Michael S. Sacks)....Pages 81-104 Tricuspid Valve Biomechanics: A Brief Review (William D. Meador, Mrudang Mathur, Manuel K. Rausch)....Pages 105-114 Measurement Technologies for Heart Valve Function (Morten O. Jensen, Andrew W. Siefert, Ikechukwu Okafor, Ajit P. Yoganathan)....Pages 115-149 Front Matter ....Pages 151-151 Calcific Aortic Valve Disease: Pathobiology, Basic Mechanisms, and Clinical Strategies (Payal Vyas, Joshua D. Hutcheson, Elena Aikawa)....Pages 153-179 Remodelling Potential of the Mitral Heart Valve Leaflet (Bruno V. Rego, Sarah M. Wells, Chung-Hao Lee, Michael S. Sacks)....Pages 181-206 Molecular and Cellular Developments in Heart Valve Development and Disease (Lindsey J. Anstine, Anthony S. Baker, Joy Lincoln)....Pages 207-239 Mechanical Mediation of Signaling Pathways in Heart Valve Development and Disease (Ishita Tandon, Ngoc Thien Lam, Kartik Balachandran)....Pages 241-262 Tissue Engineered Heart Valves (Jay M. Reimer, Robert T. Tranquillo)....Pages 263-288 Decellularization in Heart Valve Tissue Engineering (Katherine M. Copeland, Bo Wang, Xiaodan Shi, Dan T. Simionescu, Yi Hong, Pietro Bajona et al.)....Pages 289-317 Novel Bioreactors for Mechanistic Studies of Engineered Heart Valves (Kristin Comella, Sharan Ramaswamy)....Pages 319-335 Bioprosthetic Heart Valves: From a Biomaterials Perspective (Naren Vyavahare, Hobey Tam)....Pages 337-382 Front Matter ....Pages 383-383 Computational Modeling of Heart Valves: Understanding and Predicting Disease (Ahmed A. Bakhaty, Ali Madani, Mohammad R. K. Mofrad)....Pages 385-411 Biomechanics and Modeling of Tissue-Engineered Heart Valves (T. Ristori, A. J. van Kelle, F. P. T. Baaijens, S. Loerakker)....Pages 413-446 Fluid–Structure Interaction Analysis of Bioprosthetic Heart Valves: the Application of a Computationally-Efficient Tissue Constitutive Model (Rana Zakerzadeh, Michael C. H. Wu, Will Zhang, Ming-Chen Hsu, Michael S. Sacks)....Pages 447-469 Towards Patient-Specific Mitral Valve Surgical Simulations (Amir H. Khalighi, Bruno V. Rego, Andrew Drach, Robert C. Gorman, Joseph H. Gorman, Michael S. Sacks)....Pages 471-487