ENGLISH

Evolutionary Concepts in Immunology

By Robert Jack , Louis Du Pasquier

Book information

Publisher
Springer International Publishing
Year
2019
ISBN
978-3-030-18666-1;978-3-030-18667-8
Language
english
Format
PDF
Filesize
4 MB (3794790 bytes)
Edition
1st ed.
Pages
XVI, 145\156
Time added
2019-09-18 12:18:59
Biomedicine; Immunology; Evolutionary Biology; Dev

Description

Immunology is a nodal subject that links many areas of biology. It permeates the biosciences, and also plays crucial roles in diagnosis and therapy in areas of clinical medicine ranging from the control of infectious and autoimmune diseases to tumour therapy. Monoclonal antibodies and small molecule modulators of immunity are major factors in the pharmaceutical industry and now constitute a multi billion dollar business. Students in these diverse areas are frequently daunted by the complexity of immunology and the astonishing array of unusual mechanisms that go to make it up. Starting from Dobzhansky’s famous slogan, “Nothing in biology makes sense except in the light of evolution”, this book will serve to illuminate how evolutionary forces shaped immunity and thus provide an explanation for how many of its counter intuitive oddities arose. By doing so it will provide a conceptual framework on which students may organise the rapidly growing flood of immunological knowledge. Front Matter ....Pages i-xvi What Makes Evolution Tick? (Robert Jack, Louis Du Pasquier)....Pages 1-16 From Unicellular to Metazoan Immunity (Robert Jack, Louis Du Pasquier)....Pages 17-32 Innate Immunity (Robert Jack, Louis Du Pasquier)....Pages 33-69 The Triumph of Individualism: Evolution of Somatically Generated Adaptive Immune Systems (Robert Jack, Louis Du Pasquier)....Pages 71-117 The Other Side of the Arms Race (Robert Jack, Louis Du Pasquier)....Pages 119-130 Postface (Robert Jack, Louis Du Pasquier)....Pages 131-132 Back Matter ....Pages 133-145

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