Diffuse Gastric Cancer
Book information
Description
We live in an era of personalized medicine and the knowledge about pathophysiology of diffuse gastric cancer has had many advances. Thus, the role of this work is to clarify what is new from diagnosis to treatment of this disease in order to treat patients in the most tailored manner as possible. Almost all phase III trials in gastric cancer have been performed without taking in consideration histologic subtypes, i.e. they have disregarded the differences between diffuse gastric cancer and general gastric cancer. However, the clinical practice reveals that diffuse gastric cancer is a completely distinct disease, with an aggressive course and generally worse prognosis. The loss of cohesion between tumor cells due to the loss of E-cadherin synthesis is the critical point on the oncogenesis of diffuse gastric cancer and is at the root of its marked heredity. This book intends to give special attention to Diffuse Gastric Cancer as a particular oncological entity, differentiating it from general gastric cancer, exploring and discussing all its peculiarities, and addressing the basic aspects (pathology and genetics) along with the most recent therapeutic alternatives for this condition. Front Matter ....Pages i-x Introduction (Tiago Biachi de Castria, José Mauricio Mota)....Pages 1-3 Epidemiology (Williams Fernandes Barra, Samia Demachki, Geraldo Ishak, Paulo Pimentel de Assumpção)....Pages 5-14 The Role of Endoscopy (Bruno Frederico Medrado, Bruno da Costa Martins)....Pages 15-25 Pathology and Molecular Biology (Maria Aparecida Azevedo Koike Folgueira, Marina Candido Visontai Cormedi, Daniela Marques Saccaro, Maria Lucia Hirata Katayama)....Pages 27-40 Genetic Predisposition and Hereditary Syndromes (Ana Carolina Ribeiro Chaves de Gouvea, Andrea Clemente Baptista Silva, Carolina Ribeiro Victor, Elizabeth Zambrano Mendoza, Mirella Nardo, Rodrigo Santa Cruz Guindalini)....Pages 41-48 The Role of Surgery (Ulysses Ribeiro Jr., Fernando Simionato Perrotta)....Pages 49-56 The Role of Radiation Therapy (Andre Tsin Chih Chen, Carlos Bo Chur Hong)....Pages 57-64 The Role of Chemotherapy (Guilherme Luiz Stelko Pereira, Eduardo Saadi Neto)....Pages 65-75 Back Matter ....Pages 77-81
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