Tietz clinical guide to laboratory tests

Description

The fourth edition highlights four new sections. Section I, written by Sol Green, contains preanalytical factors that affect clinical laboratory data including patient status, collection factors, processing and centrifugation, and specimen transportation. This section also generically describes the dozens of blood collection tubes used in modern phlebotomy. Section VI, written by C. Mark Lu, consists of an updated catalog of the hundreds of immunophenotyping markers measured by flow cytometry and immunohistochemistry. Part I contains Cluster of Differentiation or “CD” antigens and other immunophenotypic markers, while Part II consists of immunophenotypic markers of hematopoietic and lymphoid neoplasms. Section VII, written by Steve Wong and Paul Jannetto, consists of tests useful in the emerging field of pharmacogenetics and pharmacogenomics. Part I consists of Phase I liver drug metabolizing enzymes, Part II consists of Phase II liver drug metabolizing enzymes, Part III consists of drug transporters, and Part IV consists of drug receptor targets. Section VIII, written by John Halsey, lists the tests useful for allergy detection. Table VIII-1 lists the various allergens that are commonly tested such as pollens, molds and yeasts, mites, animal proteins, foods, insects, parasites, drugs, and occupational and miscellaneous allergens. In addition to these new sections, each of the sections from the third edition has been greatly expanded. Section II consists of nearly 700 entries of the general clinical laboratory tests, with dozens of new entries and the elimination of many tests that are now obsolete. All entries have been reviewed and updated by contributors largely new to this series. For selected clinical chemistry tests, we have added new data on reference intervals for random urine concentrations, expressed as per gram of creatinine. This is the result of a large database generated by Larry Bond, Bill Ottinger, and Carl Garber for Quest Laboratories. Section III on molecular diagnostics tests written by Greg Tsongalis has been greatly expanded to reflect the many changes that this field has undergone in the last decade. In addition to a summary of molecular diagnostic techniques, tests cover the areas of infectious disease, bacteriology, cancer, genetic diseases, and identity testing. Section IV consists of therapeutic drugs written by Kiang-Teck Jerry Yeo, Hong Kee Lee, Joyce Liu Flanagan, and Catherine Hammett Stabler, and has been combined with Drugs of Abuse Testing, written by Larry Broussard. As in the previous edition, therapeutic ranges are combined with pharmacokinetic parameters. Section V, written by Yvette McCarter, Susan Sharp, Diane Halstead, and Jaber Aslanzadeh, consists of antimicrobial susceptibility tests and combined entries for over 150 microbiology tests for the identification of bacteriological, spirochetal, mycoplasmal, chlamydial, rickettsial, fungal, parasitic, and viral diseases. Tests include cultures, serologies, and special procedures. Throughout the sections, we have listed the references immediately after each entry to make this guide more user-friendly. Although this book has become a mainstay for clinical laboratories, it was also written for medical practitioners. Thus this book is a Clinical Guide to Laboratory Tests. We would like to acknowledge David Stein of Elsevier for his proof-reading assistance.