Chromogranins: from Cell Biology to Physiology and Biomedicine

Description

The volume is designed to provide an integrated overview of the results from the last fifteen years of research on Chromogranins in relation to cell biology, physiology and biomedicine. The different chapters highlight novel activities of these proteins, including their role in granule biogenesis, hormone co-storage, stimulus-processing-secretion coupling, autonomic sympathetic/parasympathetic balance, immune and cardiocirculatory function, and the response to stress. Biomedical aspects are also illustrated with focus on the prognostic and diagnostic significance of Chromogranin in the presence of tumors, cardiovascular diseases and inflammatory conditions. The volume is of interest for laboratory and clinical scientists, PhD and Post-doc students that will be inspired to go deep inside the molecular, biochemical, physiological, pharmacological and clinical aspects of these fascinating multifaceted proteins. Front Matter ....Pages i-ix History and Perspectives (Karen B. Helle)....Pages 1-19 Secretogranin II: Novel Insights into Expression and Function of the Precursor of the Neuropeptide Secretoneurin (Reiner Fischer-Colbrie, Markus Theurl, Rudolf Kirchmair)....Pages 21-38 Chromogranins as Molecular Coordinators at the Crossroads between Hormone Aggregation and Secretory Granule Biogenesis (O. Carmon, F. Laguerre, L. Jeandel, Y. Anouar, M. Montero-Hadjadje)....Pages 39-48 Involvement of Chromogranin A and Its Derived Peptides to Fight Infections (Marie-Hélène Metz-Boutigue, Francis Schneider)....Pages 49-68 Conserved Nature of the Inositol 1,4,5-Trisphosphate Receptor and Chromogranin Coupling and Its Universal Importance in Ca2+ Signaling of Secretory Cells (Seung Hyun Yoo)....Pages 69-81 Chromogranin A in Endothelial Homeostasis and Angiogenesis (Flavio Curnis, Fabrizio Marcucci, Elisabetta Ferrero, Angelo Corti)....Pages 83-98 Full Lenght CgA: A Multifaceted Protein in Cardiovascular Health and Disease (Bruno Tota, Maria Carmela Cerra)....Pages 99-112 Cardiac Physio-Pharmacological Aspects of Three Chromogranin A-Derived Peptides: Vasostatin, Catestatin, and Serpinin (Tommaso Angelone, Bruno Tota, Maria Carmela Cerra)....Pages 113-131 Comparative Aspects of CgA-Derived Peptides in Cardiac Homeostasis (Alfonsina Gattuso, Sandra Imbrogno, Rosa Mazza)....Pages 133-148 Molecular and Cellular Mechanisms of Action of CgA-Derived Peptides in Cardiomyocytes and Endothelial Cells (Giuseppe Alloatti, Maria Pia Gallo)....Pages 149-168 Chromogranin A-Derived Peptides in Cardiac Pre- and Post-conditioning (Claudia Penna, Pasquale Pagliaro)....Pages 169-193 Naturally Occurring Single Nucleotide Polymorphisms in Human Chromogranin A (CHGA) Gene: Association with Hypertension and Associated Diseases (Nitish R. Mahapatra, Sajalendu Ghosh, Manjula Mahata, Gautam K. Bandyopadhyay, Sushil K. Mahata)....Pages 195-211 Serpinin Peptides: Tissue Distribution and Functions (Y. Peng Loh, Niamh Cawley, Alicja Woronowicz, Josef Troger)....Pages 213-228 Action and Mechanisms of Action of the Chromogranin A Derived Peptide Pancreastatin (N. E. Evtikhova, A. Pérez-Pérez, C. Jiménez-Cortegana, A. Carmona-Fernández, T. Vilariño-García, V. Sánchez-Margalet)....Pages 229-247 Chromogranins and the Quantum Release of Catecholamines (Leandro Castañeyra, Michelle Juan-Bandini, Natalia Domínguez, José David Machado, Ricardo Borges)....Pages 249-260 Back Matter ....Pages 261-267