ENGLISH

Telomerases: Chemistry, Biology, and Clinical Applications

Book information

Year
2012
ISBN
9780470592045, 9781118268667
DOI
10.1002/9781118268667
Language
english
Format
PDF
Filesize
5 MB (5411183 bytes)
Pages
328\328
Orientation
yes
Scanned
yes
Time added
2013-08-01 04:00:00

Description

This book is a comprehensive and up-to-date review and evaluation of the contemporary status of telomerase research.  Chapters in this volume cover the basic structure, mechanisms, and diversity of the essential and regulatory subunits of telomerase.  Other topics include telomerase biogenesis, transcriptional and post-translational regulation, off-telomere functions of telomerase and the role of telomerase in cellular senescence, aging and cancer. Its relationship to retrotransposons, a class of mobile genetic elements that shares similarities with telomerase and serves as telomeres in selected organisms, are also reviewed.Content: Chapter 1 The Telomerase Complex: An Overview (pages 1–21): Johanna Mancini and Chantal AutexierChapter 2 Telomerase RNA: Structure, Function, and Molecular Mechanisms (pages 23–51): Yehuda Tzfati and Julian J.?L. ChenChapter 3 TERT Structure, Function, and Molecular Mechanisms (pages 53–78): Emmanuel Skordalakes and Neal F. LueChapter 4 Telomerase Biogenesis: RNA Processing, Trafficking, and Protein Interactions (pages 79–103): Tara Beattie and Pascal ChartrandChapter 5 Transcriptional Regulation of Human Telomerase (pages 105–134): Antonella Farsetti and Yu?sheng CongChapter 6 Telomerase Regulation and Telomere?Length Homeostasis (pages 135–156): Joachim Lingner and David ShoreChapter 7 Telomere Structure in Telomerase Regulation (pages 157–199): Momchil D. Vodenicharov and Raymund J. WellingerChapter 8 Off?Telomere Functions of Telomerase (pages 201–212): Kenkichi Masutomi and William C. HahnChapter 9 Murine Models of Dysfunctional Telomeres and Telomerase (pages 213–242): Yie Liu and Lea HarringtonChapter 10 Cellular Senescence, Telomerase, and Cancer in Human Cells (pages 243–263): Phillip G. Smiraldo, Jun Tang, Jerry W. Shay and Woodring E. WrightChapter 11 Telomerase, Retrotransposons, and Evolution (pages 265–299): Irina R. Arkhipova

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