Radiation Therapy for Liver Tumors : Fundamentals and Clinical Practice

Description

The management of liver tumors is a nexus of interactions among multiple medical specialties, including radiation oncology. A multitude of liver-directed therapies are available for patients, ranging from surgery and liver transplantation to intra-arterial therapies, thermal ablation procedures, systemic therapies, and radiation treatments. With the introduction of hypofractionated irradiation, particle therapy, and radioembolization, there is growing interest in the use of radiation as a treatment for liver malignancies. This book examines basic principles of the management of liver tumors. The evolving roles of x-ray and particle therapies as well as radioembolization in the treatment of liver tumors is the main focus. A theme of multidisciplinary management is also emphasized, as surgical, interventional and systemic therapies are reviewed. A unique resource that discusses the role of radiation treatment in the context of other liver-directed therapies, Radiation Therapy for Liver Tumors is of broad interest to radiation oncologists, surgeons, hepatologists, medical oncologists, and radiologists. Front Matter ....Pages i-xviii Front Matter ....Pages 1-1 Liver Anatomy and Function (Jeffrey B. Kaplan, Avash Kalra, Scott W. Biggins)....Pages 3-11 Imaging Characteristics of Normal Liver and Liver Tumors (Ali A. Haydar, Layla Antoine Nasr, Hero K. Hussain)....Pages 13-29 Assessment of Liver Function: Focus on the ALBI Score (Philip J. Johnson, Harun Khan, Sarah Berhane)....Pages 31-38 Radiation Sensitivity of the Liver: Models and Clinical Data (Issam El Naqa, Kyle Cuneo, Dawn Owen, Theodore S. Lawrence, Randall K. Ten Haken)....Pages 39-47 Radiation Oncology: Fundamentals and Controversies (Jeffrey Meyer, Tracey E. Schefter)....Pages 49-55 Front Matter ....Pages 57-57 Surgical Considerations (Ana Luiza Mandelli Gleisner)....Pages 59-68 Principles of Intra-Arterial Therapies (Keshav M. Menon, Ankaj Khosla, Clayton K. Trimmer)....Pages 69-75 Principles of Thermal Ablation (Camille L. Stewart, Barish H. Edil, Robert K. Ryu, M. Reza Rajebi)....Pages 77-88 Front Matter ....Pages 89-89 External Beam Radiation Therapy for Liver Tumors: Simulation, Treatment Planning, and Advanced Delivery Techniques (David C. Westerly, Karyn A. Goodman)....Pages 91-105 Particle Radiation Therapy for Liver Tumors: Simulation and Treatment Planning (Matthew Knecht, Andrew Wroe, Gary Y Yang)....Pages 107-119 Yttrium-90 Selective Internal Radiation Therapy (D. Thor Johnson, Adam Leon Kesner)....Pages 121-131 Interstitial Brachytherapy for Liver Tumors: Practical Issues (Michael R. Folkert, Brian Hrycushko)....Pages 133-146 Front Matter ....Pages 147-147 Hepatocellular Carcinoma: Epidemiology, Basic Principles of Treatment, and Clinical Data (Amit G Singal, Purva Gopal, Adam C Yopp)....Pages 149-178 Radiation Therapy for Hepatocellular Carcinoma: Clinical Data (Erqi L. Pollom, Yushen Qian, Julie L. Koenig, Albert C. Koong, Daniel T. Chang)....Pages 179-198 Front Matter ....Pages 199-199 Intrahepatic and Hilar Cholangiocarcinomas: Epidemiology, Basic Principles of Treatment, and Clinical Data (S. Lindsey Davis)....Pages 201-221 Radiation Therapy for Intrahepatic and Hilar Cholangiocarcinoma: Clinical Data (Sagar A. Patel, Florence K. Keane, Theodore S. Hong)....Pages 223-232 Front Matter ....Pages 233-233 Liver Metastases: Basic Principles of Treatment and Clinical Data (Matthew R. Porembka, Michael A. Choti)....Pages 235-244 Radiation Therapy for Liver Metastases: Clinical Data (Morten Høyer)....Pages 245-256 Front Matter ....Pages 257-257 Multidisciplinary Model for Liver Tumors (Cheryl Meguid, Tracey E. Schefter)....Pages 259-266 Front Matter ....Pages 267-267 Radiation Therapy for Liver Tumors: Future Directions (Eric A. Mellon, Gilbert Murimwa, Sarah E. Hoffe)....Pages 269-281 Back Matter ....Pages 283-288