Synthetic Biology: Omics Tools and Their Applications

Description

The book uses an integrated approach to predict the behavior of various biological interactions. It further discusses how synthetic biology gathers the information about various systems, in order to either devise an entirely new system, or, to modulate existing systems. The book also tackles the concept of modularity, where biological systems are visualized in terms of their parts. The chapters discuss how the principles of engineering are being used in biomedical sciences, to design biological circuits that can harbor multiple inputs and generate multiple outputs; to create genetic networks and control gene activity, in order to generate a desired response. The book aims to help the readers develop an array of biological parts, and to use these parts to develop synthetic circuits that can be assembled like electronic circuits. The ultimate aim of the book will be to serve as an amalgamation of key ideas of how judiciously synthetic biology could be exploited in therapeutic device and delivery mechanism. Front Matter ....Pages i-vii Integrated Systems and Chemical Biology Approach for Targeted Therapies (Ritika Kabra, Bhavnita Soni, Anurag Kumar, Nutan Chauhan, Prajakta Ingale, Shailza Singh)....Pages 1-19 Application of Bioengineering in Revamping Human Health (Shreya Ghosh, M. S. Kumar, Bhubaneswari Bal, A. P. Das)....Pages 21-37 Integrative Omics for Interactomes (Debangana Chakravorty, Krishnendu Banerjee, Sudipto Saha)....Pages 39-49 Studying Parasite Gene Function and Interaction Through Ribozymes and Riboswitches Design Mechanism (Harish Shukla, Timir Tripathi)....Pages 51-74 Genome Microbiology for Synthetic Applications (Taj Mohammad, Md. Imtaiyaz Hassan)....Pages 75-86 Medicinal Application of Synthetic Biology (Umesh Panwar, Poonam Singh, Sanjeev Kumar Singh)....Pages 87-94 Computational Tools for Applying Multi-level Models to Synthetic Biology (Roberta Bardini, Gianfranco Politano, Alfredo Benso, Stefano Di Carlo)....Pages 95-112 Computational Techniques for a Comprehensive Understanding of Different Genotype-Phenotype Factors in Biological Systems and Their Applications (Abhishek Subramanian, Ram Rup Sarkar)....Pages 113-139 Alignment-Free Analyses of Nucleic Acid Sequences Using Graphical Representation (with Special Reference to Pandemic Bird Flu and Swine Flu) (Ashesh Nandy, Antara De, Proyasha Roy, Munna Dutta, Moumita Roy, Dwaipayan Sen et al.)....Pages 141-188 Modern Approaches in Synthetic Biology: Genome Editing, Quorum Sensing, and Microbiome Engineering (Taj Mohammad, Md. Imtaiyaz Hassan)....Pages 189-205 Synthetic Probes, Their Applications and Designing (Shafaque Zahra, Ajeet Singh, Shailesh Kumar)....Pages 207-226 Omics-Based Nanomedicine (Chirasmita Nayak, Ishwar Chandra, Poonam Singh, Sanjeev Kumar Singh)....Pages 227-248 Characterization of Plant Genetic Modifications Using Next-Generation Sequencing (Ana Pérez-González, Álvaro Eseverri, Elena Caro)....Pages 249-259