Heterocycles via Cross Dehydrogenative Coupling: Synthesis and Functionalization

Description

This book discusses the developments in the synthesis and functionalization of different heterocycles based on the formation of carbon-carbon (C-C) and carbon-heteroatom (C-X) bonds using cross-dehydrogenative coupling (CDC). Consisting of 13 chapters, the book systematically describes the advances in the synthesis and functionalization of nitrogen, oxygen, and sulfur-containing heterocycles. It also discusses the various mechanistic pathways to help readers gain an in-depth understanding of the CDC reactions of heterocycles. Lastly, in order to promote green chemistry, it addresses a range of metal-free CDC reactions of heterocycles – an area that has attracted significant attention in both academic and industrial research. Front Matter ....Pages i-x Functionalization of Aromatic N-Heterocycles with C(sp3)–H Sources via CDC Reactions (Ramil F. Fatykhov, Igor A. Khalymbadzha, Oleg N. Chupakhin)....Pages 1-33 Functionalization of Aromatic N-Heterocycles via C(sp2)–H/C(sp2)–H CDC Reactions (Igor A. Khalymbadzha, Ramil F. Fatykhov, Oleg N. Chupakhin)....Pages 35-75 The C-1 Functionalization of Tetrahydroisoquinolines via Cross-Dehydrogenative Coupling Reactions (Marlyn C. Ortiz Villamizar, Carlos E. Puerto Galvis, Vladimir V. Kouznetsov)....Pages 77-105 Cross-Dehydrogenative Coupling in the Synthesis and Functionalization of Fused Imidazoheterocycles (Avik Kumar Bagdi, Alakananda Hajra)....Pages 107-141 Synthesis and Functionalization of N-Heterocycles Using Transition Metal-Free Cross-Dehydrogenative Coupling (CDC) Approaches (V. Murugesh, Apurba Ranjan Sahoo, Mathieu Achard, Surisetti Suresh)....Pages 143-212 Cross-Dehydrogenative Coupling of Carbonyls for Heterocycle Synthesis (Ryo Yazaki, Takashi Ohshima)....Pages 213-229 Inter- and Intramolecular Cross-Dehydrogenative Coupling of Alcohols Through the Hydrogen-Borrowing Approach (Seetharaman Manojveer, Magnus T. Johnson)....Pages 231-277 Synthesis and Functionalization of S-heterocycles via CDC Reactions (Nadale K. Downer-Riley)....Pages 279-308 Oxidative P-C Couplings and Related Reactions (Alajos Grün, György Keglevich)....Pages 309-328 Mechanistic Pathways Toward the Synthesis of Heterocycles Under Cross-Dehydrogenative Conditions (Ahmad A. Almasalma, Esteban Mejía)....Pages 329-356 Metal-Free Synthesis of Heterocycles via Cross-Dehydrogenative Coupling (Anju Modi, Bhisma K. Patel)....Pages 357-412 Photo-Driven Catalytic Cross-Dehydrogenative Coupling (CDC)-Type Reactions (Eiji Yamaguchi, Saki Maejima, Akichika Itoh)....Pages 413-444 Application of Electrochemical Cross-Dehydrogenative Couplings in the Syntheses of Heterocycles (Amit R. Nath, Chin Fei Chee, Noorsaadah Abd Rahman)....Pages 445-494