ENGLISH

Epigenetic Regulation of Lymphocyte Development

By Sven Heinz , Christopher K. Glass (auth.) , Cornelis Murre (eds.)

Book information

Publisher
Springer-Verlag Berlin Heidelberg
Year
2012
ISBN
9783642241024, 9783642241031
Language
english
Format
PDF
Filesize
5 MB (5733180 bytes)
Series
Current Topics in Microbiology and Immunology 356
Edition
1
Pages
194\197
Time added
2020-08-30 06:11:09
Immunology; Gene Expression

Description

The studies described in this volume serve as a starting point to familiarize one self with the multifarious differences in epigenetic designs that orchestrate the progression of developing blood cells. They also may serve as a general paradigm for the mechanisms that underpin the control of eukaryotic gene expression. Front Matter....Pages i-x Roles of Lineage-Determining Transcription Factors in Establishing Open Chromatin: Lessons From High-Throughput Studies....Pages 1-15 B Lymphocyte Lineage Specification, Commitment and Epigenetic Control of Transcription by Early B Cell Factor 1....Pages 17-38 Epigenetic Features that Regulate IgH Locus Recombination and Expression....Pages 39-63 Local and Global Epigenetic Regulation of V(D)J Recombination....Pages 65-89 Genetic and Epigenetic Regulation of Tcrb Gene Assembly....Pages 91-116 T-Cell Identity and Epigenetic Memory....Pages 117-143 Encoding Stability Versus Flexibility: Lessons Learned From Examining Epigenetics in T Helper Cell Differentiation....Pages 145-164 The Epigenetic Landscape of Lineage Choice: Lessons From the Heritability of Cd4 and Cd8 Expression....Pages 165-188 Back Matter....Pages 189-191

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