Sesquiterpene Lactones

Description

This book addresses chemical and biological aspects related to sesquiterpene lactones (STLs). Experts in different fields have been invited to contribute on this class of compound's chemistry, isolation and identification, biological activities (antibacterial, antifungal, antiviral, antitrypanosomal, antileishmanial,antiplasmodial, antiproliferative and antiinflammatory), synthesis, biosynthesis, derivatization and QSAR analysis. Taxonomic and chemotaxonomic aspects related to the Asteraceae family are also contributed. The book begins by describing the chemical characteristics of STLs, their classification in different skeleton types, synthesis, distribution in nature and their most important biological properties. An overview of the group's main representatives, based on their importance for human health, as well as an update of the most recently isolated STLs, follow. The authors also provide an overview of the most common methods described in the literature for the extraction, purification, identification and structure elucidation of STLs, while also highlighting more recently developed methods. Furthermore, experts in the field provide an in-depth discussion of the most commonly employed in vitro and in vivo antiprotozoal assays against the different stages of parasites, as well as STLs' properties as anticancer agents in numerous cancer cell lines and animal models. Lastly, the book presents examples of the in vitro and in vivo activity of STLs and their mechanism of antiprotozoal action, together with an analysis of ultrastructural alterations, observed using TEM techniques. The book is aimed at scientists working on natural products: both those investigating this particular group of compounds and those who wish to further explore its potential as new drugs for medical conditions such as protozoal diseases and cancer. Front Matter ....Pages i-xxii Front Matter ....Pages 1-1 Overview (Valeria P. Sülsen, Virginia S. Martino)....Pages 3-17 Ancient and Modern Concepts About the Asteraceae Taxonomy (Gustavo C. Giberti)....Pages 19-29 Chemotaxonomic Study of Sesquiterpene Lactones of Asteraceae: Classical and Modern Methods (Mateus Feitosa Alves, Luciana Scotti, Fernando Batista Da Costa, Marcus Tullius Scotti)....Pages 31-45 Biosynthesis of Sesquiterpene Lactones in Plants and Metabolic Engineering for Their Biotechnological Production (María Perassolo, Alejandra Beatriz Cardillo, Víctor Daniel Busto, Ana María Giulietti, Julián Rodríguez Talou)....Pages 47-91 Chemistry of Sesquiterpene Lactones (Francis J. Barrios)....Pages 93-117 Analytical Procedures (Valeria P. Sülsen, Cesar A. N. Catalán, Virginia S. Martino)....Pages 119-136 Spectroscopic Methods for the Identification of Sesquiterpene Lactones (Valeria P. Sülsen, Osvaldo J. Donadel, Cesar A. N. Catalán)....Pages 137-172 Front Matter ....Pages 173-173 Antitrypanosomal and Antileishmanial Activities (Andrés Sánchez Alberti, Natacha Cerny, Augusto Bivona, Silvia I. Cazorla)....Pages 175-196 Antiplasmodial Activity (Nubia Boechat, Luiz Carlos da Silva Pinheiro, Flavia Fernandes da Silveira)....Pages 197-221 Mode of Action on Trypanosoma and Leishmania spp. (María E. Lombardo, Alcira Batlle)....Pages 223-240 Contribution of Microscopy for Understanding the Mechanism of Action Against Trypanosomatids (Esteban Lozano, Renata Spina, Patricia Barrera, Carlos Tonn, Miguel A. Sosa)....Pages 241-273 Effects on Other Microorganisms (María Victoria Castelli, Silvia Noelí López)....Pages 275-301 Antiproliferative and Cytotoxic Activities (Claudia A. Anesini, María Rosario Alonso, Renzo F. Martino)....Pages 303-323 Anti-inflammatory Activity (María Rosario Alonso, Claudia A. Anesini, Renzo F. Martino)....Pages 325-346 Front Matter ....Pages 347-347 Structure-Activity and Activity-Activity Relationships of Sesquiterpene Lactones (Thomas J. Schmidt)....Pages 349-371