Nuclear Receptors in Drug Metabolism
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Description
This book gives you an updated and expert overview of nuclear hormone receptors in drug metabolism and drug development and equips you with the interdisciplinary understanding of these receptors and how they can be regulated. Pharmaceutical researchers will find this extremely useful in developing drugs for cancer, heart disease, and diabetes treatment. This comprehensive resource collects scattered materials into one handy, informative volume.Content: Chapter 1 Drug Metabolism: Significance and Challenges (pages 1–41): Chandra Prakash and Alfin D. N. VazChapter 2 Establishing Orphan Nuclear Receptors PXR and CAR as Xenobiotic Receptors (pages 43–59): Tao Li, Junichiro Sonoda and Ronald M. EvansChapter 3 Nuclear Receptor?Mediated Regulation of Phase II Conjugating Enzymes (pages 61–110): Oliver BarbierChapter 4 Nuclear Receptor?Mediated Regulation of Drug Transporters (pages 111–146): Oliver BurkChapter 5 Structure and Function of PXR and CAR (pages 147–166): X. Edward Zhou and H. Eric XuChapter 6 Xenobiotic Receptor Cofactors and Coregulators (pages 167–183): John Y. L. ChiangChapter 7 Animal Models of Xenobiotic Nuclear Receptors and their Utility in Drug Development (pages 185–210): Haibiao Gong and Wen XieChapter 8 Nuclear Receptors and Drug–Drug Interactions with Prescription and Herbal Medicines (pages 211–239): Rommel G. Tirona and Richard B. KimChapter 9 Genetic Variants of Xenobiotic Receptors and their Implications in Drug Metabolism and Pharmacogenetics (pages 241–273): Jatinder Lamba and Erin G. SchuetzChapter 10 Beyond PXR and CAR, Regulation of Xenobiotic Metabolism by other Nuclear Receptors (pages 275–300): Martin Wagner, Gernot Zollner and Michael TraunerChapter 11 Emerging Role of Retinoid?Related Orphan Receptor (ROR) and its Cross Talk with LXR (Liver X Receptor) in the Regulation of Drug?Metabolizing Enzymes (pages 301–318): Taira Wada and Wen Xie
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