Biochemistry and Cell Biology of Ageing: Part I Biomedical Science

Description

This new volume in the Subcellular Biochemistry series will focus on the biochemistry and cellular biology of aging processes in human cells. The chapters will be written by experts in their respective fields and will focus on a number of the current key areas of research in subcellular aging research. Main topics for discussion are mitochondrial aging, protein homeostasis and aging and the genetic processes that are involved in aging. There will also be chapters that are dedicated to the study of the roles of a variety of vitamins and minerals on aging and a number of other external factors (microbiological, ROS, inflammation, nutrition). This book will provide the reader with a state of the art overview of the subcellular aging field. This book will be published in cooperation with a second volume that will discuss the translation of the cell biology of aging to a more clinical setting and it is hoped that the combination of these two volumes will bring a deeper understanding of the links between the cell and the body during aging. Front Matter ....Pages i-x Antioxidant Vitamins and Ageing (Irina Milisav, Samo Ribarič, Borut Poljsak)....Pages 1-23 Autophagy: ‘Self-Eating’ Your Way to Longevity (Charlotte J. Pattison, Viktor I. Korolchuk)....Pages 25-47 Nutrient Sensing, Signaling and Ageing: The Role of IGF-1 and mTOR in Ageing and Age-Related Disease (Simon C. Johnson)....Pages 49-97 The Interplay Between Cholesterol Metabolism and Intrinsic Ageing (Mark Tomás Mc Auley)....Pages 99-118 Key Age-Imposed Signaling Changes That Are Responsible for the Decline of Stem Cell Function (Melod Mehdipour, Yutong Liu, Chao Liu, Binod Kumar, Daehwan Kim, Ranveer Gathwala et al.)....Pages 119-143 Creatine, Creatine Kinase, and Aging (Nathalie Sumien, Ritu A. Shetty, Eric B. Gonzales)....Pages 145-168 Extracellular Matrix and Ageing (Helen L. Birch)....Pages 169-190 Vitamin D and Ageing (Tom R. Hill, Antoneta Granic, Terence J. Aspray)....Pages 191-220 Telomeres, Telomerase and Ageing (Gabriele Saretzki)....Pages 221-308 Nuclear DNA Damage and Ageing (Kyriacos Agathangelou, Zisis Apostolou, George A. Garinis)....Pages 309-322 Signal Transduction Pathways in Ageing (Cathy Slack, Jennifer Tullet)....Pages 323-350 The Gut Microbiota and Ageing (Claire Maynard, David Weinkove)....Pages 351-371 Nutrition and Ageing (Fiona C. Malcomson, John C. Mathers)....Pages 373-424 Role/s of ‘Antioxidant’ Enzymes in Ageing (Elizabeth Veal, Thomas Jackson, Heather Latimer)....Pages 425-450 B Vitamins and Ageing (Kathleen Mikkelsen, Vasso Apostolopoulos)....Pages 451-470 Gene Expression, Epigenetics and Ageing (Babukrishna Maniyadath, Namrata Shukla, Ullas Kolthur-Seetharam)....Pages 471-504 Glycobiology of Aging (Fabio Dall’Olio)....Pages 505-526