ENGLISH

Synthetic Methods for Biologically Active Molecules: Exploring the Potential of Bioreductions

By Elisabetta Brenna

Book information

Publisher
Wiley-VCH
Year
2013
ISBN
3527333878, 9783527333875
Language
english
Format
PDF
Filesize
7 MB (7385146 bytes)
Edition
1
Pages
408\407
Scanned
yes
Time added
2014-07-06 17:09:08

Description

This useful reference focuses on the currently available toolbox of bio-catalysed reductions of C=O, C=C and formal C=N bonds to show which transformations can be reliably used in manufacturing processes and which still require improvements. Following an introductory chapter, chapters 2-4 present the synthetic strategies that are currently available for the reduction of C=C and C=O bonds and for reductive amination, by means of whole-cell catalysts and isolated enzymes. Chapters 5-7 go on to describe the improvements achieved thus far, illustrating the current versatility of enzymes in organic synthesis. Chapters 8-12 present the improvements brought about by the optimization of reaction conditions, and the use of particular synthetic sequences. The final chapter describes practical applications of bio-reductions for the synthesis of active pharmaceutical ingredients. With its excellent and comprehensive overview, this book will be of great interest to those working in academia and industry.From the contents:* Development of Sustainable Biocatalyzed Reduction Processes for Organic Chemists* Reductases: From Natural Diversity to Biocatalysis and Emerging Enzymatic Activities.* Synthetic Strategies Based on C=C Bioreductions* Synthetic Strategies Based on C=O Bioreductions* Development of Novel Enzymes for the Improved Reduction of C=C Double Bonds* Development of Novel Enzymes for the Improved Reduction of C=O Double Bonds* Synthetic Applications of Aminotransferases* Strategies for Cofactor Regeneration in Biocatalyzed Reductions* Effects of Solvent System and Substrate Loading in Bioreduction* Perspectives in the Use of In-Situ Product Removal (ISPR) Techniques in Bioreductions* Multi-Enzymatic Cascade Reactions Based on Reduction Processes* Relevant Practical Applications of Bioreduction Processes in the Synthesis of Active Pharmaceutical Ingredients

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