ENGLISH

Molecular Genetics of Inflammatory Bowel Disease

By Mauro D'Amato , Charlotte Hedin , John D. Rioux

Book information

Publisher
Springer International Publishing
Year
2019
ISBN
978-3-030-28702-3, 978-3-030-28703-0
Language
english
Format
PDF
Filesize
8 MB (8471491 bytes)
Edition
2nd ed. 2019
Pages
X, 402\399
Time added
2020-02-08 04:41:44
Biomedicine; Human Genetics; Molecular Medicine; G

Description

This book reaches out to a wide variety of professionals in the biomedical field with an interest in inflammatory bowel disease (IBD). Enormous progress has been made in the last few years since the publication of the first edition in the study of complex diseases and IBD, with hundreds of genomic regions identified that are associated with increased risk. Authored by leading clinical and research scientists in the field, the book includes state-of-the art synopses of recent genetic findings, and their interpretation for current and future exploitation in translational approaches to personalized medicine in IBD. The book also covers risk prediction, improved diagnostic and therapeutic precision, dissection of disease phenotypes and subtypes, identification of biomarkers, and host gene-microbiota interactions of clinical relevance. Front Matter ....Pages i-x Front Matter ....Pages 1-1 A Primer on IBD: Phenotypes, Diagnosis, Treatment, and Clinical Challenges (Katherine Falloon, Mark Lazarev)....Pages 3-24 Genetic Epidemiology of Inflammatory Bowel Disease, Early Twin and Family Studies (Jonas Halfvarson)....Pages 25-45 Experimental Models of Intestinal Inflammation: Lessons from Mouse and Zebrafish (Oscar E. Diaz, Rodrigo A. Morales, Srustidhar Das, Eduardo J. Villablanca)....Pages 47-76 Front Matter ....Pages 77-77 Complex Disease Genes and Their Discovery (Jeffrey C. Barrett, Mark J. Daly)....Pages 79-89 IBD Genomic Risk Loci and Overlap with Other Inflammatory Diseases (Fatemeh Hadizadeh, Charlie W. Lees, Catherine Labbé, John D. Rioux, Miles Parkes, Alexandra Zhernakova et al.)....Pages 91-115 Sequencing and Mapping IBD Genes to Individual Causative Variants and Their Clinical Relevance (Aleixo Muise, Hailiang Huang)....Pages 117-139 Genetic Risk Prediction in IBD (Urko M. Marigorta)....Pages 141-156 Molecular Profiling of IBD Subtypes and Therapy Responses (Ho-Su Lee, Isabelle Cleynen)....Pages 157-182 Inflammatory Bowel Disease and Epigenetics (Antonella Fazio, Dora Bordoni, Philip Rosenstiel)....Pages 183-201 MicroRNAs and Inflammatory Bowel Disease (Matthias Hübenthal, Andre Franke, Simone Lipinski, Simonas Juzėnas)....Pages 203-230 IBD Genetics and the Gut Microbiome (Shixian Hu, Alexander Kurilshikov, Alexandra Zhernakova, Rinse Weersma)....Pages 231-248 Front Matter ....Pages 249-249 NOD1 and NOD2 and the Immune Response to Bacteria (Maria Kaparakis-Liaskos, Ashleigh Goethel, Dana J. Philpott)....Pages 251-280 The IL-23/Th17 Axis in Intestinal Inflammation (Kevin J. Maloy)....Pages 281-303 Inflammatory Bowel Disease at the Intersection of Autophagy and Immunity: Insights from Human Genetics (Natalia Nedelsky, Petric Kuballa, Adam B. Castoreno, Ramnik J. Xavier)....Pages 305-328 The Epithelial Barrier (Celia Escudero-Hernández, Stefan Koch)....Pages 329-345 The Gut Microbiome in Inflammatory Bowel Disease (Aonghus Lavelle, Harry Sokol)....Pages 347-377 Front Matter ....Pages 379-379 Toward Personalized Therapy in Inflammatory Bowel Disease (Ryan C. Ungaro, Jean-Frederic Colombel)....Pages 381-389 Back Matter ....Pages 391-402

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