Esophageal Cancer Prevention, Diagnosis and Therapy
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Intro; Preface; Acknowledgments; Contents; 1: Epidemiology and Risk Factors for Esophageal Cancer; Introduction; Epidemiology; Incidence; Esophageal Adenocarcinoma; Esophageal Squamous Cell Carcinoma; Mortality; Survival; Risk Factors; Esophageal Adenocarcinoma; Age and Gender; Ethnicity; Eating Disorders; Obesity; Bulimia Nervosa; Gastroesophageal Reflux Disease; Barrett's Esophagus; Socioeconomic Status; Occupation; Helicobacter pylori Infection; Diet; Hot Food and Beverage; Meat Consumption; Fruit and Vegetables; Minerals and Vitamins; Flavonoids; Vitamin D; N-Nitrosodimethylamine (NDMA) Intro Preface Acknowledgments Contents 1: Epidemiology and Risk Factors for Esophageal Cancer Introduction Epidemiology Incidence Esophageal Adenocarcinoma Esophageal Squamous Cell Carcinoma Mortality Survival Risk Factors Esophageal Adenocarcinoma Age and Gender Ethnicity Eating Disorders Obesity Bulimia Nervosa Gastroesophageal Reflux Disease Barrett's Esophagus Socioeconomic Status Occupation Helicobacter pylori Infection Diet Hot Food and Beverage Meat Consumption Fruit and Vegetables Minerals and Vitamins Flavonoids Vitamin D N-Nitrosodimethylamine (NDMA) FolateDrugs Sex Steroids Proton Pump Inhibitors Bisphosphonates Nonsteroidal Anti-inflammatory Agents and Aspirin Statins Alcohol Consumption and Tobacco Smoking Metabolic Disorders Esophageal Squamous Cell Carcinoma Age and Gender Ethnicity Alcohol Consumption and Tobacco Smoking Socioeconomic Status Occupation Opium Diet Hot Food and Beverages Eggs Meat Consumption Pickles Tea and Coffee Consumption Minerals and Vitamins Toenail Mineral Concentration NDMA Folate Diet-Related Inflammation Maté Consumption Tooth Loss and Oral Hygiene Oral Cancer Infectious Disease Viral DiseaseHelicobacter pylori Infection Medications Bisphosphonates Conclusions References 2: Cellular and Molecular Biology of Esophageal Cancer Introduction Histological Differences Applications of Molecular and Cellular Biology Establishment of an Infectious Cofactor Human Papillomavirus Epstein-Barr Virus Bacteria Understanding Genetic Mechanisms Genetic Profiles MicroRNAs (miRNAs) Cancer Stem Cells Prognostic Information Predication of Progression Guidelines for Medical Therapies Prediction of Response to Medical Therapies Predictors for Targeted Therapy Research Sources for Molecular and Cellular Studies in Esophageal CancersTissue Studies Cancer Cell Lines Animal Models References 3: Pathology of Premalignant and Malignant Disease of the Esophagus Introduction Pathology of Adenocarcinoma and Its Precursor Lesions Precursor Lesions of Esophageal Adenocarcinoma: Barrett's Esophagus and Barrett's Esophagus-Associated Dysplasia Esophageal Adenocarcinoma Pathology of Squamous Cell Carcinoma and Its Precursor Lesions Precursor Lesions of Esophageal Squamous Cell Carcinoma Esophageal Squamous Cell Carcinoma Assessment of Specimens HER2-Neu TestingMicrosatellite Instability Testing PD-L1 Testing References 4: Barrett's Esophagus: Diagnosis and Management Introduction Natural History and Risk Factors Natural History Risk Factors for BE and EAC Risk Factors for BE and Strategies to Identify a Screening Population Risk Factors for the Progression of BE to EAC Diagnosing Barrett's Esophagus (BE): Current Criteria and Areas of Controversy Tissue-Based Diagnostic and Risk Markers BE Surveillance: Current Clinical Strategies and Features That Affect the Implementation of the Surveillance Program
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