Chiral Recognition in Separation Methods: Mechanisms and Applications
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The importance of chiral interactions for both preparative and analytical separations, particularly for pharmaceutical applications, is underlined by numerous publications in this field. Here, for the first time, a team of experienced analysts from industry and academe presents a comprehensive review of the various mechanisms that result in enantiomer separations. A better understanding of these processes is crucial for setting as well as improving chiral separation procedures and also for developing new applications. The coverage in this book includes a range of separation methods, such as gas, liquid, or countercurrent chromatography, and capillary electrophoresis. The special case of chiral ionic liquids is examined in detail. Most modern chiral selectors are discussed, including derivatized polysaccharide- and cyclodextrin-based selectors, along with a newly introduced class of carbohydrates: the cyclofructose selectors. This publication will be required reading not only for research and development departments in the pharmaceutical and cosmetic industries, but also for researchers in toxicology, environmental monitoring, and food research. Front Matter....Pages i-xiv Chiral Recognition Mechanisms in Enantiomers Separations: A General View....Pages 1-32 Preparation and Chiral Recognition of Polysaccharide-Based Selectors....Pages 33-52 Description and Evaluation of Chiral Interactive Sites on Bonded Cyclodextrin Stationary Phases for Liquid Chromatography....Pages 53-76 Cyclofructans, a New Class of Chiral Stationary Phases....Pages 77-96 Chiral Recognition and Enantioseparation Mechanisms in Capillary Electrokinetic Chromatography....Pages 97-152 Chiral Recognition Mechanism: Practical Considerations for Pharmaceutical Analysis of Chiral Compounds....Pages 153-201 Chiral Recognition with Macrocyclic Glycopeptides: Mechanisms and Applications....Pages 203-222 Vancomycin Molecular Interactions: Antibiotic and Enantioselective Mechanisms....Pages 223-240 Enantioselective Recognition in Solution: The Case of Countercurrent Chromatography....Pages 241-274 Enantioselective Properties of Nucleic Acid Aptamer Molecular Recognition Elements....Pages 275-288 Chiral Ionic Liquids in Chromatographic Separation and Spectroscopic Discrimination....Pages 289-329 Back Matter....Pages 331-337
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