ENGLISH

Molecular Genetics of Pancreatic Cancer

By Diane M. Simeone , Marco Dal Molin M.D. , Anirban Maitra M.B.B.S. (auth.) , Anirban Maitra (eds.)

Book information

Publisher
Springer-Verlag New York
Year
2013
ISBN
978-1-4614-6548-5, 978-1-4614-6549-2
DOI
10.1007/978-1-4614-6549-2
Language
english
Format
PDF
Filesize
5 MB (5581522 bytes)
Edition
1
Pages
235\238
Topic
Medicine Oncology
Orientation
yes
Scanned
yes
Time added
2013-08-01 04:00:00
Cancer Research; Cell Biology; Human Genetics

Description

Pancreatic cancer is a formidable disease, and advances in early detection and improved therapeutics have been slow to come forth. With new advances in molecular genetics in the field of pancreatic tumorigenesis, it is an opportune time to use these recent discoveries to enhance our understanding of pancreatic cancer biology and to improve outcomes in patients. In this volume, leading experts in the field shed light on these findings describing the mutational landscape of pancreatic cancer, including new inroads into our understanding of familial pancreatic cancer, epidemiology, the biology of K-ras signaling, and the emerging contribution of epigenetic alterations to disease initiation and progression. The distinctive pancreatic cancer-stroma ecosystem as determined by the dynamic interplay of inflammation, hallmark mutations, EMT, and cancer stem cells is described, and implications of these interactions in the context of development of novel, personalized therapeutic options are explored.

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