Basic Science of Oncology

Description

Discover the science of cancer — with this newly revised, essential introduction to cancer biology and genetics Here in one well-organized, reader-friendly volume, youll find everything you must know about the biology underlying cancer and its treatment, supported by the latest peer-reviewed research. Written by preeminent oncology researchers and clinicians, the book highlights the full range of important oncology topics and takes you through the biological basis of current and future biological therapy as well as more traditional approaches to cancer treatment. Presented in full color, the Fifth Edition of The Basic Science of Oncology is thoroughly updated and refreshed to reflect the latest critical thinking in oncology. For graduate students, oncologists, residents, and fellows, there can be no more useful guide to the bedrock science and practice of oncology than this all-in-one reference. Contributors vii Preface xi 1. Introduction to Cancer Biology 1 Lea Harrington, Robert G. Bristow, Richard P. Hill, and Ian F. Tannock 2. Methods of Molecular Analysis 5 Anthony M. Joshua, Paul C. Boutros, and Th omas Kislinger 3. Cancer Epidemiology 51 Gord Fehringer, Rayjean J. Hung, and Geoff rey Liu 4. Chemical Carcinogenesis 73 Denis M. Grant 5. Genomic Stability and DNA Repair 89 Shane M. Harding, Robert G. Bristow, and Lea Harrington 6. Oncogenic Viruses and Tumor Viruses 117 Fei-Fei Liu and Christopher D. Richardson 7. Oncogenes and Tumor-Suppressor Genes 147 Previn Dutt and Vuk Stambolic 8. Cellular Signaling Pathways 173 Michael Reedijk and C. Jane McGlade 9. Cell Proliferation and Death 193 Paul Jorgensen and Razqallah Hakem 10. Tumor Progression and Metastasis 219 Yang W. Shao, Rama Khokha, and Richard P. Hill 11. Angiogenesis 243 Janusz Rak 12. Tumor Growth, Microenvironment, and Metabolism 271 Rob A. Cairns, Ian F. Tannock, and Bradly Wouters 13. Heterogeneity in Cancer: The “Cancer Stem Cell” Hypothesis 295 Craig Gedye 14. Imaging in Oncology 317 David A. Jaff ray 15. Molecular and Cellular Basis of Radiotherapy 333 Shane M. Harding, Richard P. Hill, and Robert G. Bristow 16. Tumor and Normal Tissue Response to Radiotherapy 357 Richard P. Hill and Robert G. Bristow 17. Discovery and Evaluation of Anticancer Drugs 393 Aaron D. Schimmer and Ian F. Tannock 18. Pharmacology of Anticancer Drugs 419 Eric X. Chen 19. Drug Resistance 443 Susan P.C. Cole and Ian F. Tannock 20. Hormones and Cancer 469 Paul S. Rennie, Eric Leblanc, and Leigh C. Murphy 21. The Immune System and Immunotherapy 501 Linh T. Nguyen, Evan F. Lind, and Pamela S. Ohashi 22. Guide to Clinical Studies 529 Eitan Amir and Ian F. Tannock Index 553