ENGLISH

Models of viral hepatitis

By Fritz von Weizsäcker , Michael Roggendorf

Book information

Publisher
Karger Publishers
Year
2005
ISBN
3805578091, 9783805578097
Google Books ID
H6DtAtYcdTkC
Open Library ID
OL24304512M
Language
english
Format
PDF
Filesize
1 MB (1233682 bytes)
Series
Monographs in virology 25
Edition
1
Pages
173\173
Orientation
yes
Scanned
no
Time added
2011-08-31 04:54:40

Description

Viral hepatitis B or C is the most common cause of chronic liver disease worldwide and accounts for about 80% of all hepatocellular carcinoma cases. Thus, combating viral hepatitis remains one of the most pressing public health issues today. Animal models and cell-based systems are essential tools for addressing the many still unresolved basic and clinical problems. Experimental models are needed to better understand the viral life cycles, pathogenetic aspects and natural defense mechanisms, while preclinical models are required for evaluating novel preemptive and therapeutic strategies. This monograph provides a unique synopsis of currently available models of viral hepatitis, highlighting their particular use for basic and translational science. Leading experts discuss new scientific results and evolving methods in various animal and in vitro models, including the woodchuck, duck, mouse, chimpanzee and tupaia, as well as primary hepatocytes and subgenomic HCV replicons.A valuable

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