ENGLISH

In chemico skin sensitisation : direct peptide reactivity assay (DPRA).

Book information

Year
2015
ISBN
9789264229709, 9264229701
Language
english
Format
PDF
Filesize
2 MB (1670107 bytes)
Series
OECD guidelines for the testing of chemicals
Pages
\56
Time added
2021-10-17 10:57:33

Description

LIGNE DIRECTRICE DE L’OCDE POUR LES ESSAIS DE PRODUITS CHIMIQUES Approches définies pour la sensibilisation cutanée Tableaux Graphiques 1. Introduction 1.1. Introduction générale 1.2. Approches définies et scénarios d’utilisation figurant dans la Ligne directrice 1.3. Limites 1.3.1. Limites des différentes sources d’information in chemico/in vitro 1.3.2. Limites des différentes sources d’information in silico 1.3.3. Limites des AD 1.4. Bibliographie 2. PARTIE I – Approches définies pour l’identification du danger de sensibilisation cutanée 2.1. Approche définie « 2 sur 3 » (2o3) 2.1.1. Résumé 2.1.2. Procédure d’interprétation des données 2.1.3. Description et limites des différentes sources d’information 2.1.4. Degré de confiance dans les prédictions de l’AD 2o3 2.1.5. Capacité prédictive de l’AD 2o3 comparée à l’ELGL 2.1.6. Capacité prédictive de l’AD 2o3 comparée aux données humaines 2.1.7. Capacité prédictive de l’ELGL comparé aux données humaines 2.1.8. Substances d’épreuve de compétence 2.1.9. Rapport d’application de l’AD 2.2. Bibliographie 3. PARTIE II – Approches définies pour la catégorisation de la puissance de sensibilisation cutanée 3.1. Approche définie : « Stratégie d’essai intégrée (ITS) » 3.1.1. Résumé 3.1.2. Procédure d’interprétation des données 3.1.3. Description et limites des différentes sources d’information 3.1.4. Degré de confiance dans les prédictions de l’AD ITS 3.1.5. Capacité prédictive de l’AD ITSv1 comparée à l’ELGL 3.1.6. Capacité prédictive de l’AD ITSv2 comparée à l’ELGL 3.1.7. Capacité prédictive de l’AD ITSv1 comparée aux données humaines 3.1.8. Capacité prédictive de l’AD ITSv2 comparée aux données humaines 3.1.9. Capacité prédictive de l’ELGL comparé aux données humaines 3.1.10. Substances d’épreuve de compétence 3.1.11. Rapport d’application de l’AD 3.2. Bibliographie Annexe 1. Modèle prédictif applicable aux essais in chemico/in vitro comportant plusieurs épreuves utilisés dans l’AD 2o3 Annexe 2. Définition du domaine d’applicabilité et du degré de confiance des protocoles de prédiction in silico et de l’AD ITS Introduction Domaines d’applicabilité des différentes sources d’information Sources d’information in chemico/in vitro (DPRA et h-CLAT) Source d’information in silico Derek Nexus (ITSv1) Boîte à outils QSAR de l’OCDE (ITSv2) Degré de confiance dans les prédictions de l’ITS Comment appliquer la procédure d’interprétation des données à l’ITS Bibliographie Appendice 1. Protocole applicable aux prédictions Derek Nexus Protocole applicable pour générer des prédictions sur le danger de sensibilisation cutanée avec Derek Nexus v.6.1.0 et Derek KB 2020 1.0 Appendice 2. Protocole applicable aux prédictions de la boîte à outils QSAR de l’OCDE Protocole applicable pour générer des prédictions sur le danger de sensibilisation cutanée avec le DASS AW de la boîte à outils v4.5. Appendice 3. Informations sur le domaine d’applicabilité de la boîte à outils QSAR de l’OCDE Considérations techniques Calcul du domaine in silico de la boîte à outils Calcul des couches du domaine d’applicabilité 1. Couche paramétrique 2. Couche structurale 3. Couche mécanistique

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