Lymphatic Structure and Function in Health and Disease

Description

Lymphatic Structure and Function in Health and Disease serves as a resource book on what has been learned about lymphatic structure, function and anatomy within different organ systems. This is the first book to bring together lymphatic medicine as a whole, with in-depth analysis of specific aspects of lymphatics in different vascular pathologies. This book is a useful tool for scientists, practicing clinicians and residents, in particular, those in vascular biology, neurology, cardiology and general medicine. Chapters discuss topics such as ontogeny and phylogeny of lymphatics, lymphatic pumping, CNS lymphatics, lymphatics in transplant and lymphatic reconstruction. Brings together lymphatic medicine as a whole, with an in-depth analysis of the specific basic science aspects of lymphatic structure and functionCovers the clinical aspects of lymphatics in different vascular pathologiesCo-published with the International Society of Neurovascular DiseasesDiscusses lymphatic structure and function in all of the major organ systems Cover LYMPHATIC STRUCTURE AND FUNCTION IN HEALTH AND DISEASE Copyright Dedication Contributors About the Editors 1 Introduction/overview 2 Ontogeny and phylogeny of lymphatics: Embryological aspect Historical background Ontogenic point of view Phylogenetic point of view Vasculogenetic point of view Conclusion References Further reading 3 Lymphatic pumping and pathological consequences of its dysfunction The lymphatic system Origin and mechanisms of lymphatic pumping Electrical activity and pacemaker of the lymphatic muscle Mechanisms of lymphatic contraction Regulation of lymphatic pumping Mechanical regulation Chemical regulation Lymphatic alterations during disease Lymphadenopathy Lymphangiogenesis Lymphangiectasia Lymphatic pumping in diseases Primary lymphedema Secondary lymphedema Changes during chronic inflammation Arthritic diseases Inflammatory bowel disease Metabolic syndrome and diabetes Cancer Targeting the lymphatic pump for therapeutic benefits Conclusions References 4 Hydrodynamic regulation of lymphatic vessel transport function and the impact of aging Concepts of intrinsic and extrinsic lymph pumps Intrinsic lymph pump Extrinsic lymph pump Modulation of the lymphatic vessel contractility by pressure/stretch Modulation of the lymphatic vessel contractility by intrinsic and extrinsic flows Histamine as endothelium-derived relaxing factor in mesenteric lymphatic vessels Influences of aging References 5 CNS lymphatics in health and disease Lymphatics of the central nervous system The perivascular pathway The glymphatic pathway The meningeal pathway The role of the lymphatic system in diseases of the CNS Alzheimer's disease Multiple sclerosis Cerebral ischemic injury and microinfarcts Aging Exploiting the CNS lymphatics for drug discovery Maximizing drug delivery into the lymphatics Summary Acknowledgments References 6 Defective development of the peripheral lymphatic system: Lymphatic malformations General aspects Embryological aspects Clinical aspects Genetic considerations (see Table 1) Management References 7 Cardiac lymphatics and cardiac lymph flow in health and disease Cardiac lymphatics Flow of lymph in the heart Lymphatics within different cardiac structures Cardiac inflammation and lymphatics Valves in lymphatic vessels Cardiac conditions that may be exacerbated by lymphatic obstruction, lymphangitis, or obliteration Effects of experimental ablation of cardiac lymphatics Experimental manipulation of lymphatics as a form of cardiac therapy Summary References Further reading 8 Lymphatic reconstruction Introduction History of surgical approaches for lymphatic reconstruction Current options for lymphatic reconstruction Lymphaticovenular anastomosis Vascularized lymph node transfer Lympholymphatic graft Conclusion References Index A C D E F G H I K L M N O P R S T V Back Cover