ENGLISH

Adeno-Associated Virus Vectors: Design and Delivery

By Michael J. Castle

Book information

Publisher
Humana Press
Year
2019
ISBN
1493991388, 9781493991389
Language
english
Format
PDF
Filesize
9 MB (9837586 bytes)
Edition
Hardcover
Pages
426\420
Time added
2019-03-28 10:36:27

Description

This volume provides a complete and timely guide to the use of adeno-associated virus (AAV) vectors for genetic manipulation of mammalian tissues. Beginning with methods for the design and characterization of AAV vectors, the book continues with protocols for AAV delivery to various components of the central nervous system, to a number of sensory systems, and to a broad range of other tissues. Novel techniques such as ultrasound-targeted delivery to the brain, subpial delivery to the spinal cord, and subILM delivery to the retina are accompanied by chapters that provide an overview and comparison of current methods for AAV delivery to tissues such as brain, heart, liver, and lung. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, readily reproducible step-by-step laboratory protocols, and tips for troubleshooting and avoiding known pitfalls. Authoritative and comprehensive, Adeno-Associated Virus Vectors: Design and Delivery aims to enhance the utility of AAV vectors for targeted gene transfer to living animals and continue the ongoing development of novel AAV-based gene therapies for human disease. Front Matter ....Pages i-xii Front Matter ....Pages 1-1 Design of AAV Vectors for Delivery of RNAi (Florie Borel, Christian Mueller)....Pages 3-18 Design of AAV Vectors for Delivery of Large or Multiple Transgenes (Aman Patel, Junling Zhao, Dongsheng Duan, Yi Lai)....Pages 19-33 Ligand Coupling to the AAV Capsid for Cell-Specific Gene Transfer (Johanna Reul, Alexander Muik, Christian J. Buchholz)....Pages 35-50 Quantitative and Digital Droplet-Based AAV Genome Titration (Julio Sanmiguel, Guangping Gao, Luk H. Vandenberghe)....Pages 51-83 Single-Stranded DNA Virus Sequencing (SSV-Seq) for Characterization of Residual DNA and AAV Vector Genomes (Emilie Lecomte, Adrien Leger, Magalie Penaud-Budloo, Eduard Ayuso)....Pages 85-106 In Situ Hybridization for Detection of AAV-Mediated Gene Expression (Jacqueline E. Hunter, Brittney L. Gurda, Sea Young Yoon, Michael J. Castle, John H. Wolfe)....Pages 107-122 Use of AAV Vectors for CRISPR-Mediated In Vivo Genome Editing in the Retina (Wenhan Yu, Zhijian Wu)....Pages 123-139 Front Matter ....Pages 141-141 Intravenous Infusion of AAV for Widespread Gene Delivery to the Nervous System (Dominic J. Gessler, Phillip W. L. Tai, Jia Li, Guangping Gao)....Pages 143-163 Intraspinal and Intracortical Delivery of AAV Vectors for Intersectional Circuit Tracing in Non-transgenic Species (James M. Conner, Greg L. Bain, Jennifer N. Dulin)....Pages 165-176 MRI-Guided Focused Ultrasound for Targeted Delivery of rAAV to the Brain (Zeinab Noroozian, Kristiana Xhima, Yuexi Huang, Brian K. Kaspar, Sebastian Kügler, Kullervo Hynynen et al.)....Pages 177-197 AAV-Mediated Gene Delivery to the Spinal Cord by Intrathecal Injection (Cristina D. Peterson, Alexander G. J. Skorput, Kelley F. Kitto, George L. Wilcox, Lucy Vulchanova, Carolyn A. Fairbanks)....Pages 199-207 Subpial AAV Delivery for Spinal Parenchymal Gene Regulation in Adult Mammals (Mariana Bravo-Hernández, Takahiro Tadokoro, Martin Marsala)....Pages 209-233 Front Matter ....Pages 235-235 Peripheral AAV Injection for Retrograde Transduction of Dorsal Root and Trigeminal Ganglia (David C. Bloom, Zachary L. Watson, Donna M. Neumann)....Pages 237-247 SubILM Injection of AAV for Gene Delivery to the Retina (Paul D. Gamlin, John J. Alexander, Sanford L. Boye, C. Douglas Witherspoon, Shannon E. Boye)....Pages 249-262 Intracameral Delivery of AAV to Corneal Endothelium for Expression of Secretory Proteins (Jeffrey O’Callaghan, Matthew Campbell, Peter Humphries)....Pages 263-270 AAV-Mediated Gene Delivery to the Inner Ear (Omar Akil, Lawrence Lustig)....Pages 271-282 Intranasal Delivery of Adenoviral and AAV Vectors for Transduction of the Mammalian Peripheral Olfactory System (Cedric R. Uytingco, Jeffrey R. Martens)....Pages 283-297 AAV-Mediated Gene Delivery to Taste Cells of the Tongue (Akiyuki Taruno, Makiko Kashio)....Pages 299-307 Front Matter ....Pages 309-309 AAV Vectors for Efficient Gene Delivery to Rodent Hearts (Estrella Lopez-Gordo, Erik Kohlbrenner, Michael G. Katz, Thomas Weber)....Pages 311-332 AAV-Mediated Gene Delivery to the Liver: Overview of Current Technologies and Methods (Brett Palaschak, Roland W. Herzog, David M. Markusic)....Pages 333-360 AAV-Mediated Gene Delivery to the Lung (Laura P. van Lieshout, Jakob M. Domm, Sarah K. Wootton)....Pages 361-372 Simplified Purification of AAV and Delivery to the Pancreas by Intraductal Administration (Ping Guo, John Wiersch, Xiangwei Xiao, George Gittes)....Pages 373-387 rAAV-Mediated Gene Delivery to Adipose Tissue (Wei Huang, Nicholas J. Queen, Lei Cao)....Pages 389-405 AAV-Mediated Gene Delivery to the Enteric Nervous System by Intracolonic Injection (Reshma Gore, Maureen S. Riedl, Kelley F. Kitto, Carolyn A. Fairbanks, Lucy Vulchanova)....Pages 407-415 Back Matter ....Pages 417-426

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