ENGLISH

Comprehensive Biomarker Discovery and Validation for Clinical Application

By David , Horvatovich , Peter; Bischoff , Rainer; Thurston , David E; Fox , David; Rotella

Book information

Publisher
Royal Society of Chemistry
Year
2012
ISBN
9781849734226, 1849734224
DOI
10.1039/9781849734363-FP001
Language
english
Format
PDF
Filesize
10 MB (10153109 bytes)
Pages
384\384
Time added
2013-09-05 20:00:00

Description

Content: Introduction to biomarker discovery and validation; Clinical context of proteomics biomarker discovery and validation, authority regulations; Biomarker discovery: Patient selection; Biomarker discovery: Experimental design and biobanking; Biomarker discovery: body fluids; Biomarker discovery: tissues; Biomarker discovery: mass spectrometry based profiling platforms; Biomarker discovery: array based profiling platforms; Biomarker discovery: data preprocessing for LC-MS data; Biomarker discovery: data preprocessing for Maldi imaging, and 2D electrophoresis and protein arrays data; Biomarker discovery: statistical analysis and validation; Biomarker validation: biomarker validation methods; Functional biomarker validation; Clinical application: case studies Clinical application: summary and future technology development trends

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