Orbital Tumors: Diagnosis and Treatment
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From the Preface: “About every ten years a new book appears on any given medical specialty subject. Naturally, this is not because the entire body of knowledge on that specialty is overhauled every ten years but because the progress made over a decade usually warrants expressing new perspectives on quite a few diseases. Orbital oncology certainly qualifies as a subspecialty that merits an update every decade. At least two or three excellent textbooks on orbital tumors have been written since the mid-1980s. This book reports advances in knowledge about orbital diseases and their treatment and offers an up-to-date, single-volume reference for orbital tumors with particular emphasis on new improvements in diagnostic and therapeutic measures. Part I comprises advances in oncogenesis and its relationship to orbital tumors. Changes in the biological behavior of diseases in the general patient population are much slower than technological advances; nevertheless, those alterations take place as well. One of the major medical issues of our time, for example, is the changes in the immunological status of individuals. This issue influences the entire field of medicine, particularly oncology, including the treatment of orbital tumors. Chapters 2 to 5 summarize these influences. Medical genetics gained momentum during the past two decades and now affects the clinical practice of almost every discipline of medicine, including ophthalmology and orbitology. Chapters on principles of molecular genetics and immunosurveillance mechanisms of neoplasia and on the occurrence of multiplt, malignant neoplasms in retinoblastoma have been included to apply molecular concepts to clinical practice related to orbital tumors. Advances in one discipline often directly benefit practice in another field. In orbitology, no development has been more influential than the revolution in imaging techniques, including ultrasonography, computerized tomography, and magnetic resonance methods. Four chapters in Part II are devoted to the role of imaging in diganosis of orbital tumors. Other diagnostic advances entailing immunohistochemistry, flow cytometry, gene microarray, and the polymerase chain reaction are summarized in a separate chapter on orbital biopsy.” Orbital Tumors Diagnosis and Treatment......Page 1 Preface......Page 5 Acknowledgments......Page 7 Contents......Page 8 Contributors......Page 11 PART ONE Current Concepts of Oncogenesis......Page 14 CHAPTER 1: MOLECULAR MODELS OF CANCER DEVELOPMENT......Page 15 CHAPTER 2: IMMUNE SURVEILLANCE AND CANCER PATHOGENESIS......Page 26 CHAPTER 3: ORBITAL AND PERIORBITAL TUMORS......Page 39 CHAPTER 4: MECHANISMS OF TUMOR METASTASIS IN THE ORBIT......Page 46 CHAPTER 5: MULTIPLE MALIGNANCIES IN RETINOBLASTOMA......Page 53 PART TWO: DIAGNOSIS OF ORBITAL TUMORS......Page 60 CHAPTER 6: CLINICAL EVALUATION OF THE ORBIT......Page 61 CHAPTER 7: NEURO-OPHTHALMOLOGIC EVALUATION OF THE ORBIT......Page 71 CHAPTER 8: ULTRASONOGRAPHY IN ORBITAL DIFFERENTIAL DIAGNOSIS......Page 83 CHAPTER 9: THE BASICS OF ORBITAL IMAGING......Page 94 CHAPTER 10: IMAGING IN ORBITAL DIFFERENTIAL DIAGNOSIS......Page 104 CHAPTER 11: NEW CONCEPTS IN ORBITAL IMAGING......Page 114 CHAPTER 12: ORBITAL BIOPSY......Page 123 PART THREE: PRIMARY TUMORS OF THE ORBIT......Page 140 CHAPTER 13: ORBITAL LYMPHOMA......Page 141 CHAPTER 14: VASCULAR TUMORS......Page 149 CHAPTER 15: FIBROHISTIOCYTIC TUMORS......Page 171 CHAPTER 16: FIBRO-OSSEOUS AND CARTILAGINOUS TUMORS AND TUMORLIKE CONDITIONS......Page 182 CHAPTER 17: PERIPHERAL NERVE TUMORS......Page 195 CHAPTER 18: LACRIMAL GLAND TUMORS......Page 212 CHAPTER 19: TUMORS OF THE LACRIMAL DRAINAGE SYSTEM......Page 229 PART FOUR: SECONDARY TUMORS OF THE ADULT ORBIT......Page 239 CHAPTER 20: EYELID AND PERIOCULAR SKIN TUMORS......Page 240 CHAPTER 21: CONJUNCTIVAL TUMORS......Page 252 CHAPTER 22: OCULAR TUMORS......Page 264 CHAPTER 23: TUMORS OF THE CRANIAL AND NASAL CAVITIES AND PARANASAL SINUSES......Page 273 CHAPTER 24: METASTATIC TUMORS......Page 286 PART FIVE: PEDIATRIC ORBITAL TUMORS AND PSEUDOTUMORS......Page 297 CHAPTER 25: BENIGN PEDIATRIC TUMORS......Page 298 CHAPTER 26: MALIGNANT PEDIATRIC TUMORS......Page 309 PART S I X : TUMORLIKE CONDITIONS IN THE ORBIT......Page 320 CHAPTER 27: ORBITAL INFLAMMATION AND INFECTION VERSUS NEOPLASIA......Page 321 CHAPTER 28: GRAVES DISEASE......Page 332 CHAPTER 29: MASS-FORMING INFLAMMATORY LESIONS OF THE ORBIT......Page 339 PART SEVEN: MANAGEMENT OF ORBITAL TUMORS......Page 355 CHAPTER 30: STAGING OF ORBITAL TUMORS......Page 356 CHAPTER 31: SURGICAL TREATMENT......Page 362 CHAPTER 32: COMPUTER IMAGE GUIDANCE AND SKULL-BASE STRATEGIES......Page 394 CHAPTER 33: RADIATION TREATMENT......Page 401 CHAPTER 34: CHEMOTHERAPY FOR CHILDHOOD TUMORS......Page 413 CHAPTER 35: CHEMOTHERAPY FOR ADULT TUMORS......Page 425 Index......Page 436
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