Glyceraldehyde-3-phosphate Dehydrogenase (GAPDH). The Quintessential Moonlighting Protein in Normal Cell Function and in Human Disease

Description

Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH): The Quintessential Moonlighting Protein in Normal Cell Function and in Human Disease examines the biochemical protein interactions of the multi-dimensional protein GAPDH, further considering the regulatory mechanisms through which cells control their functional diversity. This protein’s diverse activities range from nuclear tRNA export and the maintenance of genomic integrity, to cytoplasmic post-transcriptional control of gene expression and receptor mediated cell signaling, to membrane facilitation of iron metabolism, trafficking and fusion. This book will be of great interest to basic scientists, clinicians and students, including molecular and cell biologists, immunologists, pathologists and clinical researchers who are interested in the biochemistry of GAPDH in health and disease. Content: Dedication,Front Matter,Copyright,Biography,Acknowledgments,IntroductionEntitled to full textSection I: The Role of Moonlighting GAPDH in Normal Cell FunctionChapter 1 - The Role of Moonlighting GAPDH in Cell Proliferation: The Dynamic Nature of GAPDH Expression and Subcellular Localization, Pages 3-20 Chapter 2 - Moonlighting GAPDH and the Transcriptional Regulation of Gene Expression: Multiprotein Complex Formation and Mechanisms of Nuclear Translocation, Pages 21-33 Chapter 3 - The Diversity of Moonlighting GAPDH Function in Posttranscriptional RNA Regulation: mRNA Stability, tRNA Processing, and Viral Pathogenesis, Pages 35-56 Chapter 4 - The Role of Moonlighting GAPDH in Membrane Structure and Function: Membrane Fusion and Iron Metabolism, Pages 57-76 Chapter 5 - The Role of Moonlighting GAPDH in Intracellular Membrane Trafficking: Tubulin Regulation and Modulation of Cytoskeletal Structure, Pages 77-95 Chapter 6 - Moonlighting GAPDH and the Maintenance of DNA Integrity: Preservation of Genetic Information and Cancer Facilitation, Pages 97-111 Chapter 7 - Moonlighting GAPDH in Neuronal Structure and Function: Regulation of Ion Channels and Signal Transduction, Pages 113-128 Chapter 8 - The Significance of Nitric Oxide–Modified GAPDH: Regulation of Apoptosis, Cell Signaling, and Heme Metabolism, Pages 131-154 Chapter 9 - GAPDH and Hypoxia: Mechanisms of Cell Survival During Oxygen Deprivation, Pages 155-165 Chapter 10 - Moonlighting GAPDH and Ischemia: Cellular and Molecular Effects of Oxygen Deprivation and Reperfusion, Pages 167-178 Chapter 11 - GAPDH and Tumorigenesis: Molecular Mechanisms of Cancer Development and Survival, Pages 181-197 Chapter 12 - Moonlighting GAPDH and Age-Related Neurodegenerative Disease: Diversity of Protein Interactions and Complexity of Function, Pages 199-219 Chapter 13 - Functional Diversity of GAPDH in Infection and Immunity: The Complexity of “Simple” Organisms, Pages 221-239 Chapter 14 - Moonlighting GAPDH and Diabetes: Pleiotropic Effects of Perturbations in GAPDH Structure and Function, Pages 241-257 Section IV - The Pharmacology of Moonlighting GAPDH, Pages 259-277 Section V - The Unique Role of Sperm-Specific GAPDH, Pages 279-295 Section VI - Discussion, Pages 297-298 Index, Pages 299-306