ENGLISH

Global Strategies for Disease Detection and Treatment (Disease Markers)

By S. Hanash

Book information

Year
2002
ISBN
1586032496, 9781586032494, 9780585458816
Open Library ID
OL20525548M
Language
english
Format
PDF
Filesize
15 MB (15872359 bytes)
Pages
112\115
Topic
Medicine Diseases
Time added
2011-06-04 13:46:07

Description

The field of proteomics holds great promise for identifying non-targeted, global molecular profiles "signatures" of normal and diseased cells. While genomics offers an array of tools for identifying mutated or dysregulated genes, proteonomics offers the ability to measure post-translational modifications, protein stability, phosphorylation state, protein-protein interactions, and protein DNA-binding affinities. This work shows that strategies based on the separate analysis of subcellular compartments provide the means to determine protein location in a cell. Selective enrichment for a subset of proteins of interest can be achieved using a variety of techniques from centrifugation procedures to affinity capture.

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