Precision Medicine in Cancer Therapy

Description

This book presents the latest advances in precision medicine in some of the most common cancer types, including hematological, lung and breast malignancies. It also discusses emerging technologies that are making a significant impact on precision medicine in cancer therapy. In addition to describing specific approaches that have already entered clinical practice, the book explores new concepts and tools that are being developed. Precision medicine aims to deliver personalized healthcare tailored to a patient’s genetics, lifestyle and environment, and cancer therapy is one of the areas in which it has flourished in recent years. Documenting the latest advances, this book is of interest to physicians and clinical fellows in the front line of the war on cancer, as well as to basic scientists working in the fields of cancer biology, drug development, biomarker discovery, and biomedical engineering. The contributing authors include translational physicians with first-hand experience in precision patient care. Front Matter ....Pages i-x Front Matter ....Pages 1-1 Targeted Therapies in Non-small-Cell Lung Cancer (Addie Hill, Rohan Gupta, Dan Zhao, Ritika Vankina, Idoroenyi Amanam, Ravi Salgia)....Pages 3-43 Update on Precision Medicine in Breast Cancer (Jasgit C. Sachdev, Ana C. Sandoval, Mohammad Jahanzeb)....Pages 45-80 The Role of Precision Medicine in the Diagnosis and Treatment of Patients with Rare Cancers (Michael J. Demeure)....Pages 81-108 Front Matter ....Pages 109-109 Immunohistochemistry-Enabled Precision Medicine (Zoran Gatalica, Rebecca Feldman, Semir Vranić, David Spetzler)....Pages 111-135 Genomics-Enabled Precision Medicine for Cancer (Alison Roos, Sara A. Byron)....Pages 137-169 Utilization of Proteomic Technologies for Precision Oncology Applications (Mariaelena Pierobon, Julie Wulfkuhle, Lance A. Liotta, Emanuel F. Petricoin III)....Pages 171-187 Precision Medicine-Enabled Cancer Immunotherapy (John K. Lee, Saul J. Priceman)....Pages 189-205 Front Matter ....Pages 207-207 Use of Precision Imaging in the Evaluation of Pancreas Cancer (Ronald L. Korn, Syed Rahmanuddin, Erkut Borazanci)....Pages 209-236 Single-Cell Sequencing in Precision Medicine (Julia E. Wiedmeier, Pawan Noel, Wei Lin, Daniel D. Von Hoff, Haiyong Han)....Pages 237-252 Human Microbiota and Personalized Cancer Treatments: Role of Commensal Microbes in Treatment Outcomes for Cancer Patients (Stephen Gately)....Pages 253-264 Artificial Intelligence and Personalized Medicine (Nicholas J. Schork)....Pages 265-283