Energy Balance and Gastrointestinal Cancer

Description

The gastrointestinal track provides one of the distinct systems where multiple malignancies, including adenocarcinoma of the pancreas, esophagus and colon are each associated with obesity. This unique association is covered in this volume of Energy Balance and Cancer from the epidemiologic, biologic and potential etiologic viewpoint. The focus on possible dietary contribution as well as the role of exercise in prevention and therapy is presented in both animal model and patient based studies. Special focus is provided also on the role of genetic mutations and inflammatory pathways as drivers of these obesity related gastrointestinal malignancies. Overall, this volume on Energy Balance and Gastrointestinal Malignancies should be valuable to Epidemiologists, Gastroenterologists and Oncologists, as well as to students and researchers from multiple disciplines interested in understanding and disrupting the association between obesity and cancer. Front Matter....Pages i-xii Obesity and Gastrointestinal Cancers: Epidemiology....Pages 1-22 Genetics of Colon Cancer Susceptibility....Pages 23-45 Dietary Modulation of Colon Cancer: Effects on Intermediary Metabolism, Mucosal Cell Differentiation, and Inflammation....Pages 47-64 The Apc Min/+ Mouse Model to Study the Effects of Exercise on Gastrointestinal Malignancy....Pages 65-75 Obesity and the Pathogenesis of Barrett’s Esophagus....Pages 77-92 Obesity and Pancreatic Cancer....Pages 93-109 Obesity, Insulin Resistance Pathway Factors, and Colon Cancer....Pages 111-129 Ras/Raf and Their Influence in Glycolysis in Colon Cancer....Pages 131-139 Energy Balance and Other Modifiable Host Factors on Colorectal Cancer Prognosis....Pages 141-156 Cyclooxygenase-2 and Chronic Inflammation: Drivers of Colorectal Tumorigenesis....Pages 157-182 Back Matter....Pages 183-184