Site-Selective Neurotoxicity

Description

Taylor & Francis, 2002. - 308 p.List of figures. List of tables. List of contributors. Preface to the series. Preface.Introduction. Principles of neurotoxicology. Site-selective action.Molecular-specific actions. Targets of free radical toxicity. Neurotrophic factors and synaptic plasticity in the adult hippocampus. Cholinergic muscarinic receptors as targets for neurotoxicity. Nicotinic acetylcholine receptors, beta-adrenergic receptors and lung cancer. Molecular neurotoxicology implications of acetylcholinesterase. Potassium channels.Cellular-selective toxicity. Motor neurons. The cerebellar granule cell. Purkinje cells: a significant target for neurotoxicity. Neuronal degeneration in the forebrain produced by amphetamine, methamphetamine and fenfluramine. The astrocyte response to neural injury: a review and reconsideration of key features.Tissue-selective toxicity. Detecting neurotoxic damage to the circumventricular organs (CVOs): susceptible brain tissues located outside the blood–brain barrier. Mechanisms of peripheral neurotoxicity. Index.