ENGLISH

An Introduction to Clinical Neuroendocrinology

By Michael Wilkinson; Ali Imran

Book information

Publisher
Cambridge University Press
Year
2018
ISBN
1316645193, 9781316645192
Language
english
Format
PDF
Filesize
88 MB (92262692 bytes)
Pages
320\207
Time added
2020-05-13 15:05:06

Description

This innovative, introductory text is authored by key subject leaders in clinical neuroendocrinology with decades of research and teaching experience. Addressing the need for a concise description of human neuroendocrine systems, this important review of various significant basic science advances is relevant to all levels of experience. An indispensable resource for a variety of learners, this book will also enable biomedical science graduate students, to extend their knowledge using its valuable clinical context. Beautifully illustrated, the text integrates basic scientific principles with clinical cases, and includes several illustrated imaging studies and in-depth discussions of basic principles and their interpretations. Extensive reference lists of clinical papers, teaching resources and a selection of review questions are included with each chapter, emphasizing the real-life importance of basic neuroendocrine principles in human health and disease. Clinical reviews are included to provide convenient links to more specialized texts, ensuring a successful springboard for learners, worldwide. Contents Preface Acknowledgments 1 Basic Principles in Clinical Neuroendocrinology I: Receptor Mechanisms 1.1 Cell Membrane Receptors 1.2 G Protein-Coupled Receptors 1.3 Tyrosine Kinase-Dependent Receptors 1.4 Intracellular Receptors for Steroid Hormones 1.5 Chapter Summary 1.6 Review Questions 2 Basic Principles in Clinical Neuroendocrinology II: Assays, Rhythms and Pulses 2.1 Determination of Hormone Levels 2.2 Patterns of Hormone Secretion 2.3 Chapter Summary 2.4 Review Questions 3 Neuroendocrinology of Female Reproduction 3.1 The Menstrual Cycle 3.2 Neural Control of GnRH Secretion 3.3 Pulsatile Secretion of LH 3.3.1 A Case of Delayed Puberty 3.4 Neurochemical Regulation of GnRH Secretion 3.4.1 A Case of OHSS and KP 3.5 Chapter Summary 3.6 Review Questions 4 Neuroendocrine Regulation of Appetite and Body Weight 4.1 The Neural Control of Appetite 4.2 Leptin: A Fat-Derived Peptide Hormone 4.3 Other Genetic Forms of Obesity 4.4 Gastrointestinal Peptides: The Gut–Brain Axis 4.4.1 A Case of Hypothalamic Obesity 4.4.2 A Case of Drug-Induced Obesity 4.5 Chapter Summary 4.6 Review Questions 5 Hypothalamic–Pituitary–Adrenal Cortex Axis 5.1 Cortisol Synthesis and Assessment of Cortisol Secretion 5.2 Regulation of ACTH Secretion: Neurotransmitter/Neuropeptide Control 5.3 Regulation of ACTH Secretion: GC Negative Feedback 5.4 Pulsatile Secretion of ACTH and Cortisol 5.5 Stress and the HPA Axis 5.6 Food Intake and the HPA Axis 5.7 Body Weight and the HPA Axis 5.7.1 A Case of Cushing’s Disease 5.7.2 A Case of Cortisol Deficiency 5.8 Chapter Summary 5.9 Review Questions 6 Hypothalamic Regulation of Thyroid Function 6.1 The Hypothalamic–Pituitary–Thyroid Axis 6.2 Neural Control of TRH/TSH Secretion 6.3 TH Feedback Regulating TSH Secretion 6.4 Insensitivity to THs 6.5 Rhythmic and Pulsatile Secretion of TSH 6.6 TH and Energy Balance 6.7 Thyroid Function in Critical Illness 6.8 THs and Fertility 6.8.1 A Case of Hyperthyroidism 6.8.2 A Case of Hypothyroidism 6.9 Chapter Summary 6.10 Review Questions 7 Hypothalamic Regulation of Prolactin Secretion 7.1 Regulation of PRL Secretion 7.2 Dopamine and PRL Secretion 7.3 Drugs and PRL Release 7.4 Sleep and Pulsatile PRL Secretion 7.5 Chest Wall Trauma and PRL Secretion 7.6 Breastfeeding and PRL Secretion 7.7 Effect of Sex Hormones on PRL 7.8 PRL Release and Sexual Activity 7.9 Stress-Induced PRL Secretion 7.10 Obesity and PRL Secretion 7.11 Hyperprolactinemia 7.11.1 A Case of Prolactinoma 7.12 Chapter Summary 7.13 Review Questions 8 Regulation of Growth Hormone Secretion 8.1 Regulation of GH Secretion 8.2 Pulsatile Secretion 8.3 Other Factors Regulating GH Secretion 8.4 Neural Control of GH Secretion 8.5 Receptor Mechanisms that Control GH Secretion from Somatotrophs 8.6 Receptor Mechanism for GH Stimulation of IGF-1 Production in Liver Cells 8.7 GH Excess 8.7.1 A Case of Gigantism 8.8 GH Deficiency 8.8.1 A Case of growth hormone deficiency 8.9 Chapter Summary 8.10 Review Questions 9 Posterior Pituitary 9.1 Neuroanatomy of the Hypothalamic–Posterior Pituitary System 9.2 Central Regulation of VP and OXY Secretion 9.3 OXY Secretion 9.4 Effects of OXY on Eating Behavior 9.5 VP Secretion 9.6 VP Secretion and Water Homeostasis 9.7 Disorders of VP Secretion 9.7.1 A Case of DI 9.7.2 A Case of SIADH 9.8 Baroregulation of VP Secretion 9.9 Behavioral Effects of VP and OXY in Humans 9.10 Chapter Summary 9.11 Review Questions 10 An Introduction to Sellar Masses 10.1 History and Assessment of Patients with an SM 10.2 Nonfunctioning Adenomas 10.3 Prolactinomas 10.4 GH Adenomas (Gigantism and Acromegaly) 10.5 ACTH Adenomas (Cushing’s Disease) 10.6 TSH Adenoma 10.7 Non-pituitary SM 10.8 Less Common SM 10.9 Chapter Summary 10.10 Review Questions Appendix Answers to Review Questions Index

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