Handbook of Small Animal Imaging: Preclinical Imaging, Therapy, and Applications

Description

The use of small animal models in basic and preclinical sciences constitutes an integral part of testing new pharmaceutical agents prior to their application in clinical practice. New imaging and therapeutic approaches need to be tested and validated first in animals before application to humans. Handbook of Small Animal Imaging: Preclinical Imaging, Therapy, and Applications collects the latest information about various imaging and therapeutic technologies used in preclinical research into a single source. Useful to established researchers as well as newcomers to the field, this handbook shows readers how to exploit and integrate these imaging and treatment modalities and techniques into their own research. The book first presents introductory material on small animal imaging, therapy, and research ethics. It next covers ionizing radiation and nonionizing radiation methods in small animal imaging, hybrid imaging, and imaging agents. The book then addresses therapeutic research platforms and image quantification, explaining how to ensure accurate measurements of high-quality data. It concludes with an overview of many small animal imaging and therapy applications that demonstrate the strength of the techniques in biomedical fields. Cover Half Title Title Page Copyright Page Dedication Table of Contents Series Preface Preface Editors Contributors Section I—Introduction to Small Animal Imaging, Therapy, and Applications Chapter 1. Defining Small Animal Imaging, Therapy, and Applications Chapter 2. Ethics and Regulations for Research with Animals Chapter 3. Small Animal Handling, Care, and Anesthesia Chapter 4. Preclinical Models Section II—Small Animal Imaging: Ionizing Radiation Chapter 5. Microcomputed Tomography Chapter 6. Digital Subtracted Angiography of Small Animals Chapter 7. Single-Photon Emission Computed Tomography Chapter 8. Positron Emission Tomography Section III—Small Animal Imaging: Nonionizing Radiation Chapter 9. MR Imaging Chapter 10. Optical Imaging Section IV—Hybrid Imaging Chapter 11. Optical-CT Imaging Chapter 12. PET/CT Chapter 13. Introduction to Combining MRI with PET Chapter 14. Exotic Imaging Approaches Section V—Imaging Agents Chapter 15. X-Ray, MRI, and Ultrasound Agents: Basic Principles Chapter 16. Radiochemistry for Preclinical Imaging Studies Chapter 17. Molecular Targets and Optical Probes Section VI—Therapeutic Research Platforms Chapter 18. Developing Technologies for Small Animal Radiotherapy Chapter 19. Dosimetry of Ionizing Radiation in Small Animal Imaging Chapter 20. Treatment Planning for Small Animals Chapter 21. Radiolabeled Agents for Molecular Imaging and/or Therapy Section VII—Image Quantification Chapter 22. Quantification in Nuclear Preclinical Imaging Chapter 23. Performance Assessment of Small Animal Imaging Systems and Common Standards Chapter 24. Monte Carlo Simulations in Imaging and Therapy Section VIII—Applications Chapter 25. Small Animal Imaging and Therapy: How They Affect Patient Care Chapter 26. Applications for Drug Development Chapter 27. Imaging of Intracellular Targets Chapter 28. Imaging of Cell Trafficking and Cell Tissue Homing Chapter 29. Imaging of Cardiovascular Disease Chapter 30. Imaging Angiogenesis Chapter 31. Imaging of Hypoxia, Apoptosis, and Inflammation Chapter 32. Vessel Wall Imaging Index