ENGLISH

Cardiac Extracellular Matrix: Fundamental Science to Clinical Applications

By Peiman Hematti , Eric G. Schmuck , Amish N. Raval

Book information

Publisher
Springer International Publishing
Year
2018
ISBN
978-3-319-97420-0;978-3-319-97421-7
Language
english
Format
PDF
Filesize
6 MB (5894091 bytes)
Series
Advances in Experimental Medicine and Biology 1098
Edition
1st ed.
Pages
XII, 246\252
Time added
2019-01-12 07:55:43
Life Sciences; Cell Biology; Cardiology; Biomedica

Description

This book on cardiac extracellular matrix (ECM) features three sections, Fundamental Science, Pre-Clinical and Translational Science, and Clinical Applications. In the Fundamental Science section, we will cover the spectrum of basic ECM science from ECM’s role in development, biomechanical properties, cardiac ECM influence of cardiomyocyte biology, pathophysiology of ECM in heart disease, and ECM in tissue engineering. Section two, Preclinical and Translational Science, will discuss cardiac ECM technologies in the clinical pipeline including approaches to ECM as a therapeutic, animal models of cardiac research, tracking and imaging methods of cardiac ECM, and cGMP manufacturing and regulatory considerations for ECM based therapeutics. Finally, the third section, Clinical Applications, will highlight the clinical experience around cardiac ECM including therapeutic strategies targeting scar tissue in the heart, Clinical trial design and regulatory considerations, current human clinical trials in cardiovascular medicine and the role of pharmaceutical and biotech companies in the commercialization of ECM technologies for cardiovascular indications. This book provides a comprehensive review for basic and translational researchers as well as clinical practitioners and those involved in commercialization, regulatory and entrepreneurial activities. Front Matter ....Pages i-xii Biomechanical Properties and Mechanobiology of Cardiac ECM (Michael Nguyen-Truong, Zhijie Wang)....Pages 1-19 Imaging the Cardiac Extracellular Matrix (Michael A. Pinkert, Rebecca A. Hortensius, Brenda M. Ogle, Kevin W. Eliceiri)....Pages 21-44 Animal Models and Cardiac Extracellular Matrix Research (Timothy A. Hacker)....Pages 45-58 Applications of Cardiac Extracellular Matrix in Tissue Engineering and Regenerative Medicine (Mark C. Daley, Spencer L. Fenn, Lauren D. Black III)....Pages 59-83 Whole Cardiac Tissue Bioscaffolds (Karis R. Tang-Quan, Nicole A. Mehta, Luiz C. Sampaio, Doris A. Taylor)....Pages 85-114 Natural Sources of Extracellular Matrix for Cardiac Repair (Keith L. Spinali, Eric G. Schmuck)....Pages 115-130 Cardiac Extracellular Matrix Modification as a Therapeutic Approach (Mikayla L. Hall, Brenda M. Ogle)....Pages 131-150 Extracellular Matrix for Myocardial Repair (Jenna L. Dziki, Stephen F. Badylak)....Pages 151-171 Role of Extracellular Matrix in Cardiac Cellular Therapies (Peiman Hematti)....Pages 173-188 Regulation of Regenerative Medicine Products (Adrian P. Gee)....Pages 189-198 Clinical Trial Design for Investigational Cardio-Regenerative Therapy (Amish N. Raval)....Pages 199-211 Regenerative Medicine Venturing at the University-Industry Boundary: Implications for Institutions, Entrepreneurs, and Industry (Adam J. Bock, David Johnson)....Pages 213-236 Back Matter ....Pages 237-246

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