Proteases in Human Diseases

Description

Front Matter....Pages i-xvii Front Matter....Pages 1-1 Matrix Metalloproteinases in Breast Carcinoma....Pages 3-20 Multifaceted Role of Matrix Metalloproteases on Human Diseases....Pages 21-40 Complex Mechanisms of Matrix Metalloproteinases Involvement in Endometrial Physiology and Pathology—An Update....Pages 41-67 Role of Metalloproteinases in Melanoma Growth and Progression....Pages 69-90 Cysteine Cathepsins: In Health and Rheumatoid Arthritis....Pages 91-102 Proteases in Neuropathophysiology....Pages 103-130 Proteases in Wound Healing and Immunity....Pages 131-145 Translating the Knowledge of Functional Dynamics Toward Designing Inhibitors of BACE1, a Key Aspartate Protease in Alzheimer’s Disease....Pages 147-170 Serine Proteases and Their Inhibitors in Human Health and Disease....Pages 171-193 Metalloproteases and Human Diseases: The Astacin Family....Pages 195-226 Proteases of Parasitic Helminths: Their Metabolic Role in Establishment of Infection in the Host....Pages 227-245 Natural Polyphenols as Prospective Inhibitors for MMPs Remodeling in Human Diseases....Pages 247-262 Autophagic Proteases: Functional and Pathophysiological Aspects....Pages 263-283 ADAM and ADAMTS Family of Metalloproteinases: Role in Cancer Progression and Acquisition of Hallmarks....Pages 285-301 Role of Proteases in Lung Disease: A Brief Overview....Pages 303-331 Caspases: Moonlighting Proteins with Theranostic Potential....Pages 333-374 Functional Aspects of Activated Protein C (APC) in Regulating Homeostasis and Disease....Pages 375-393 Front Matter....Pages 395-408 Role of Calpains (Calcium-Dependent Proteases) on Coronary Artery Disease and Metabolic Syndrome....Pages 409-409 Role of Matrix Metalloproteinases in the Development and Progression of Atherosclerosis....Pages 411-423 Front Matter....Pages 425-446 Protease Cathepsins in Cardiomyopathy: From Mechanism to Intervention....Pages 409-409 Cysteine-Dependent Aspartate-Specific Proteases in Coronary Artery Disease....Pages 447-462 Association of Matrix Metalloproteinases with CVD: Functional Aspects....Pages 463-471 microRNAs-Mediated MMPs Regulation: Novel Mechanism for Cardiovascular Diseases....Pages 473-496 ....Pages 497-513