Recurrent Implantation Failure

Description

This unique text discusses the wide range of causes and pathophysiologic conditions contributing to recurrent implantation failure (RIF) and the current treatment approaches to best approach this challenging patient population. Beginning with a presentation of the mechanism of normal implantation, the physiologic synchrony between embryo and endometrium, and the roles of both gametes and embryos in RIF, the book then examines the various genetic, immune and environmental factors involved. Abnormalities of the hematologic and endocrine system, as well as those of the anatomy and microbiome, are described in detail. Last but no less important, the psychological stress and treatment of patients experiencing RIF is discussed. Assisted reproductive technology (ART) success has increased substantially over the past three decades. However, despite these advances, recurrent implantation failure is still a common issue confronting patients and clinicians, and RIF represents one of the greatest challenges in ART and remains a source of frustration and disappointment for patients, clinicians, and researchers involved in the process. Providing an in-depth investigation into the pathophysiology and biological mechanisms of RIF and its clinical management, this will be an excellent resource for reproductive endocrinologists and infertility specialists. Front Matter ....Pages i-xiii Signaling Between Embryo and Endometrium: Normal Implantation (Chelsea Fox, Bruce A. Lessey)....Pages 1-19 Embryo and Endometrial Synchrony in Implantation Failure (Jason M. Franasiak, Richard T. Scott)....Pages 21-31 Spermatogenesis: Fertile Ground for Contributing to Recurrent Implantation Failure? (Sorena Keihani, Jeremy B. Myers, James M. Hotaling)....Pages 33-58 Embryonic Factors Associated with Recurrent Implantation Failure (Daniel J. Kaser, Catherine Racowsky)....Pages 59-75 The Genetics of Pregnancy Failure (Eric J. Forman, Nathan Treff, Rebekah S. Zimmerman)....Pages 77-91 Immune Factors in Recurrent Implantation Failure (Diana Alecsandru, Juan A. Garcia-Velasco)....Pages 93-102 Stress and Implantation Failure (Jeffrey L. Deaton, Bonnie Patel, Erika Johnston-MacAnanny, Jie Yu, Shannon D. Whirledge, Alexandra Wilson et al.)....Pages 103-124 Hematologic Disease in Implantation Failure (Shelby A. Neal, Jason M. Franasiak, Richard T. Scott)....Pages 125-134 Endocrine Causes of Implantation Failure (Scott Morin, Baris Ata, Emre Seli)....Pages 135-152 Anatomic Abnormalities and Recurrent Implantation Failure (Jeffrey M. Goldberg, Julian Gingold, Natalia Llarena)....Pages 153-174 Microbiome in Embryonic Implantation and Implantation Failure (Jason M. Franasiak, Inmaculada Moreno, Carlos Simon)....Pages 175-195 Psychosocial Implications of Recurrent Implantation Failure (Andrea Mechanick Braverman, Keren Sofer)....Pages 197-210 Back Matter ....Pages 211-215