ENGLISH

Drug Discovery from Natural Products

By Olga Genilloud

Book information

Publisher
Royal Society of Chemistry
Year
2012
ISBN
9781849733618, 9781849734950, 1849733619
Language
english
Format
PDF
Filesize
86 MB (89834970 bytes)
Series
RSC drug discovery series, 25
Pages
416\435
Time added
2013-09-05 20:00:00

Description

Content: Introduction; Part one: Semisynthesis/ synthesis de novo of NPs: Semisynthesis approach of Ecteinascidin 743 (ET-743, Yondelis(R)); Chondramides and Chivosazoles - Two metabolites which interfere with the actin cytoskeleton; Class III lantibiotics - an emerging family of thioether containing peptidesMutant manufacturers; progress in enhancing the neurotrophic effects of natural FKBP ligands; Part two: Engineering NP synthetic pathways and genome mining: biosynthesis of indolocarbazole alkaloids and generation of novel derivatives by combinatorial biosynthesis; new lantibiotics from natural and engineered strains; mining microbial genomes for metabolic products of cryptic pathways; mining cyanobacterial genomes for drug-like and bioactive natural products; pigenetic approaches to natural product synthesis in fungi; Part three: New methodologies and screening technologies for the exploitation of microbial resources: novel approaches for exploiting microbial resources at Fundacion MEDINA; discovery and development of Platensimycin and Platencin; coupling chemical genomics and natural products: the discovery of parnafungins and novel antifungal leads; Part four: Novel microbial natural products and derivatives: Retapamulin-a first-in-class pleuromutilin antibiotic; natural products: new agents against MDR tuberculosis; the contribution of marine chemistry in the field of antimalarial research; epothilones as lead structures for new anticancer drugs; future challenges

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