ENGLISH

Targeted Therapies: Mechanisms of Resistance

By Alexis B. Cortot , Pasi A. Jänne (auth.) , Daniel Gioeli (eds.)

Book information

Publisher
Humana Press
Year
2011
ISBN
1607614774, 9781607614777, 1607614782, 9781607614784
DOI
10.1007/978-1-60761-478-4
Google Books ID
CB6JunDvGFcC
Open Library ID
OL25090433M
Language
english
Format
PDF
Filesize
3 MB (3561730 bytes)
Series
Molecular and Translational Medicine
Edition
1
Pages
202\217
Orientation
yes
Scanned
no
Time added
2012-02-14 18:00:00
Oncology; Molecular Medicine; Cancer Research

Description

This volume explores the mechanisms of resistance to targeted therapeutics. The focus is on the cancer cell signaling network, although other mechanisms of resistance including target mutation, and new areas of study such as cancer stem cells are included. Targeted Therapies: Mechanisms of Resistance highlights examples of changes in the signaling network in response to inhibition of a signaling event and underscores the importance in having a mechanistic understanding of the signaling network in cancer for developing effective targeted cancer therapies. Moreover, cutting edge tools to analyze the cell signaling network will be discussed. This includes the leading edge of techniques as well as computational biology and systems theory. This volume provides the reader with both an overview as well as a detailed perspective on the mechanisms of resistance to targeted therapeutics and will be of great value to the oncologist, the physician-scientist treating patients and the translational scientist working on any aspect of targeted therapeutics.

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