ENGLISH

Numerical Methods for the Life Scientist: Binding and Enzyme Kinetics Calculated with GNU Octave and MATLAB

By Heino Prinz (auth.)

Book information

Publisher
Springer-Verlag Berlin Heidelberg
Year
2011
ISBN
978-3-642-20819-5, 978-3-642-20820-1
DOI
10.1007/978-3-642-20820-1
Language
english
Format
PDF
Filesize
7 MB (7764809 bytes)
Edition
1
Pages
149\154
Orientation
yes
Scanned
yes
Time added
2013-08-01 04:00:00
Bioinformatics; Computational Biology/Bioinformati

Description

Enzyme kinetics, binding kinetics and pharmacological dose-response curves are currently analyzed by a few standard methods. Some of these, like Michaelis-Menten enzyme kinetics, use plausible approximations, others, like Hill equations for dose-response curves, are outdated. Calculating realistic reaction schemes requires numerical mathematical routines which usually are not covered in the curricula of life science. This textbook will give a step-by-step introduction to numerical solutions of non-linear and differential equations. It will be accompanied with a set of programs to calculate any reaction scheme on any personal computer. Typical examples from analytical biochemistry and pharmacology can be used as versatile templates. When a reaction scheme is applied for data fitting, the resulting parameters may not be unique. Correlation of parameters will be discussed and simplification strategies will be offered.

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