Self-Assembled Molecules – New Kind of Protein Ligands: Supramolecular Ligands

Description

The subject of this book relates to protein ligands with particular structural and complexation properties. They are composed of self-assembled molecules, capable of penetrating as a unit into proteins outside the binding site. The ribbon-like supramolecular system only permits the penetration of self-assembled molecules into the protein-body and formation of stable complexes. Supramolecular Congo red and similar compounds fit these requirements. Destabilized protein fragments enable the penetration of such ligands, with susceptibility to supramolecular ligand binding often associated with protein function. As a result, complexation modifies their functional effects. The activity of enzymes is inhibited by arresting them in the complexed state, but “naturally irreversible” complexation as in the case of immune complexation, is enhanced instead. This property offers many attractive possibilities of using supramolecular ligands as described in this book. This book is an open access under a CC BY license. Front Matter ....Pages i-xii Supramolecular Systems as Protein Ligands (Joanna Rybarska, Barbara Piekarska, Barbara Stopa, Grzegorz Zemanek, Leszek Konieczny, Irena Roterman)....Pages 1-20 Supramolecular Congo Red as Specific Ligand of Antibodies Engaged in Immune Complex (Anna Jagusiak, Joanna Rybarska, Barbara Piekarska, Barbara Stopa, Leszek Konieczny)....Pages 21-41 Protein Conditioning for Binding Congo Red and Other Supramolecular Ligands (Grzegorz Zemanek, Anna Jagusiak, Joanna Rybarska, Piotr Piwowar, Katarzyna Chłopaś, Irena Roterman)....Pages 43-60 Metal Ions Introduced to Proteins by Supramolecular Ligands (Olga Woźnicka, Joanna Rybarska, Anna Jagusiak, Leszek Konieczny, Barbara Stopa, Irena Roterman)....Pages 61-76 Possible Mechanism of Amyloidogenesis of V Domains (Mateusz Banach, Barbara Kalinowska, Leszek Konieczny, Irena Roterman)....Pages 77-100 Supramolecular Structures as Carrier Systems Enabling the Use of Metal Ions in Antibacterial Therapy (J. Natkaniec, Anna Jagusiak, Joanna Rybarska, Tomasz Gosiewski, Jolanta Kaszuba-Zwoińska, Małgorzata Bulanda)....Pages 101-120 Congo Red Interactions with Single-Walled Carbon Nanotubes (Anna Jagusiak, Barbara Piekarska, Katarzyna Chłopaś, Elżbieta Bielańska)....Pages 121-132 Back Matter ....Pages 133-136