ENGLISH

Drug-Membrane Interactions: Analysis, Drug Distribution, Modeling

By Raimund Mannhold , Hugo Kubinyi , Gerd Folkers , Joachim K. Seydel , Michael Wiese

Book information

Publisher
Wiley-VCH
Year
2002
ISBN
9783527304271, 3-527-30427-4
LCC
RM301.42 .S49 2002
Open Library ID
OL3585064M
Language
english
Format
PDF
Filesize
3 MB (3302777 bytes)
Series
Methods and Principles in Medicinal Chemistry 15
Edition
1
Pages
369\369
Library
torrents.ru tech collections 2009-11-14
Time added
2010-01-11 02:35:34
Медицинские дисциплины;Фармацевтика;Медицинская хи

Description

Barrier, reservoir, target site - those are but some of the possible functions of biological lipid membranes in the complex interplay of drugs with the organism. A detailed knowledge of lipid membranes and of the various modes of drug-membrane interaction is therefore the prerequisite for a better understanding of drug action. Many of today's pharmaceuticals are amphiphilic or catamphiphilic, enabling them to interact with biological membranes. Crucial membrane properties are surveyed and techniques to elucidate drug-membrane interactions presented, including computer-aided predictions. Effects of membrane interaction on drug action and drug distribution are discussed, and numerous examples are given. This unique reference volume builds on the authors' long experience in the study of drug-membrane interaction. Recommended reading for everyone involved in pharmaceutical research.

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