UHMWPE Biomaterials for Joint Implants: Structures, Properties and Clinical Performance

Description

This book presents a comprehensive, state-of-the-art review of the latest progresses in UHMWPE biomaterials, which has been critical for the performance and longevity of joint implants. Oriented by clinical challenges to UHMWPE-based joint implants, it introduces the processing, crosslinking, structural manipulation, oxidation mechanism, stabilization, drug delivery, and wear, as well as clinical performance, biomechanics, and simulated studies of joint implant based on UHMWPE with low wear, which are aimed to tackle or minimize the adverse effect related to wear and wear debris. These contributions provide fundamentals of chemistry and physics of UHMWPEs to help understand the clinical performances of UHMWPE based joint implants. Perspectives to next generation UHMWPE to meet the unmet challenges in clinical use are included. Front Matter ....Pages i-x Clinical Applications of UHMWPE in Joint Implants (Jing Chen, Guorong Gao, Jun Fu)....Pages 1-20 Highly Crosslinked UHMWPE for Joint Implants (Guorong Gao, Jun Fu)....Pages 21-68 Oxidation in Prosthetic UHMWPE (L. Costa)....Pages 69-91 Natural Polyphenol-Stabilized Highly Cross-Linked UHMWPE for Joint Implants (Jun Fu)....Pages 93-114 High-Temperature Melted, Cross-Linked, and Stabilized Ultrahigh Molecular Weight Polyethylene (Jun Fu, Ebru Oral, Orhun K. Muratoglu)....Pages 115-150 Drug-Loaded UHMWPE to Inhibit Wear Particle-Induced Osteolysis: Processing, Characterization, and Biological Evaluation (Shuxin Qu, Yumei Liu, Kemeng Gong)....Pages 151-190 Biomechanics and Tribology of Artificial Knee Joint (Zhenxian Chen, Jing Zhang, Xiao Zhang, Zhong-Min Jin)....Pages 191-239 Biomechanics and Biotribology of UHMWPE Artificial Hip Joints (Yongchang Gao, Zhong-Min Jin)....Pages 241-286 Clinical Application of Roentgen Stereophotogrammetric Analysis Technique to Detect Hip Aseptic Loosening (Jin-Wu Wang, Yuan-Jing Xu, Han Yang, Ke-Rong Dai)....Pages 287-316 Wear and Diagnostic Analysis of Clinical Failures of Artificial Hip Joints (Jin-Wu Wang, Han Yang, Cheng-Tao Wang, Zhong-Min Jin, Ke-Rong Dai)....Pages 317-339