Plasmonic Optical Fiber Biosensors

Description

Plasmonic OpticalFiber Biosensors Contents Foreword Acknowledgments Chapter 1Introduction 1.1 Rationale: Optical Fibers Versus Kretschmann Prism 1.2 Positioning of the Book Content 1.3 Content Review 1.4 Practical Considerations Chapter 2Physical Concepts on Surface Plasmon Sensing 2.1 Mathematical Formalism 2.1.1 Maxwell Equations 2.1.2 Constitutive Equations 2.1.3 Boundary Conditions 2.1.4 Wave Equations 2.1.5 Plasmons at a Single Interface 2.2 Excitation of Surface Plasmons 2.3 Long-Range Surface Plasmons 2.4 Prism Configurations and Optical Fiber Counterpart 2.5 Localized Surface Plasmons 2.6 Plasmonic Materials 2.7 Signal Analysis and Performance Indicators 2.7.1 Signal Analysis 2.7.2 Performance Indicators References Chapter 3 Multimode Optical Fiber Platforms 3.1 Light Propagation in Optical Fibers 3.1.1 Geometrical Approach 3.1.2 Electromagnetism Approach 3.2 Overview of Multimode Optical Fibers 3.3 Unclad or Etched Configurations 3.4 Tapered Configurations 3.5 D-Shaped Configurations 3.6 U-Bent Configurations 3.7 Interferometers: Hetero-Core Structures 3.8 Fiber End Facets References Chapter 4Single-Mode Optical Fiber Platforms 4.1 Overview of Single-Mode Optical Fibers 4.2 Etched, Tapered, and D-Shaped Configurations 4.3 Thinned Uniform Fiber Bragg Grating Configurations 4.3.1 Basics on Uniform Fiber Bragg Gratings 4.3.2 Temperature Sensitivity of Uniform FBGs 4.3.3 Axial Strain Sensitivity of Uniform FBGs 4.3.4 Pressure Sensitivity of Uniform FBGs 4.3.5 Transverse Strain Sensitivity of Uniform FBGs 4.3.6 Refractometric Sensitivity of Uniform FBGs 4.4 Weakly and Highly Tilted Fiber Bragg Gratings 4.4.1 Weakly Tilted Fiber Bragg Gratings 4.4.2 Excessively Tilted Fiber Bragg Gratings 4.5 Eccentric Fiber Bragg Gratings 4.6 Long-Period Fiber Gratings References Chapter 5Specialty Optical Fiber Platforms 5.1 Polarization-Maintaining Optical Fibers 5.1.1 Introduction to the Concept of Polarization-Maintaining Optical Fibers 5.1.2 Use of Polarization-Maintaining Optical Fibers for Plasmonic Excitation 5.2 Microstructured Optical Fibers 5.3 Polymer Optical Fibers 5.4 Bioresorbable Optical Fibers 5.5 Fibers Incorporated with Metal Nanoparticles References Chapter 6Immunosensors 6.1 Introduction to Biochemical Sensors 6.2 Antibodies 6.3 Nanobodies 6.4 Affimers 6.5 Application of Immunosensors 6.5.1 Immobilization Strategies 6.5.2 Immunosensors 6.5.3 SPR Signal Analysis 6.6 Conclusion References Chapter 7Nucleic Acid-Based Receptors (DNA and RNA) 7.1 DNA Receptors 7.1.1 Binding DNA Receptors on Glass 7.1.2 Binding DNA Receptors on Plastic 7.1.3 Binding DNA Receptors on Metals 7.1.4 Binding DNA Receptors on Polymeric Materials 7.1.5 DNA Spot Arrays and Microstructures 7.1.6 Design and Synthesis of Specific DNA 2-D/3-D Structures 7.2 RNA/miRNA Receptors 7.3 Aptamers 7.4 Applications of Nucleic Acid-Based Biosensors 7.4.1 Hybridization/Complementary Strand Detection 7.4.2 Protein, Toxin, and Organic Compound Detection 7.4.3 Cell Detection 7.4.4 Ion Detection 7.5 Conclusion References Chapter 8Other Bioreceptors for Plasmonic Biosensors 8.1 MIPs 8.2 Enzymes 8.2.1 Enzymatic Biosensors 8.2.2 Glucose Biosensors 8.2.3 Snapshot on Other Enzymatic Biosensors 8.2.4 The Case of ELISA 8.2.5 Immobilization of Enzymes on Different Surfaces 8.2.6 Optical Fiber-Based Enzymatic Biosensors 8.3 Proteins 8.3.1 Anchor Proteins (A, G, L) 8.3.2 Protein/Antibodies or Protein/Protein Interactions 8.4 Cells 8.5 Additional Layers and Matrices 8.5.1 Hydrogels 8.5.2 Dextran Matrices 8.6 Optical Fiber-Based Applications References Chapter 9Combined Plasmonic Sensors 9.1 Electro-Plasmonics 9.1.1 Voltammetry 9.1.2 Conductometry 9.1.3 Amperometry 9.1.4 Potentiometry 9.1.5 Combination with Plasmonic Optical Fiber Sensing 9.2 Magneto-Plasmonics 9.3 Fluorescence-Based and Quantum Dot-Based Plasmonics 9.4 Raman Scattering 9.5 Ultrasound and Radio-Plasmonics References Chapter 10Current Developments and Future Challenges 10.1 Integrated Optical Fiber Devices 10.1.1 Microfluidics 10.1.2 Optofluidics 10.1.3 Smartphone-Based Optical Fiber Sensors 10.1.4 Multiplexing 10.2 Towards Commercial Practices 10.3 POC Sensing and Related Innovation 10.4 Towards In Situ Sensing 10.5 Artificial Intelligence-Assisted Sensing 10.6 From Sensing to Imaging References Chapter 11Conclusion Acronyms and Abbreviations About the Authors Index