ENGLISH

Nuclear Receptors as Drug Targets

By Eckhard Ottow (Editor) , Hilmar Weinmann (Editor) , Raimund Mannhold (Series Editor) , Hugo Kubinyi (Series Editor) , Gerd Folkers (Series Editor)

Book information

Publisher
Wiley-VCH
Year
2008
ISBN
978-3527318728
Language
english
Format
PDF
Filesize
4 MB (4616979 bytes)
Series
Methods and Principles in Medicinal Chemistry (Book 39)
Edition
1
Pages
522\523
Scanned
no
Time added
2010-02-18 13:16:04
Медицинские дисциплины;Фармацевтика;Медицинская хи

Description

G protein-coupled receptors (GPCRs) are one of the most important target classes in pharmacology and are the target of many blockbuster drugs. Yet only with the recent elucidation of the rhodopsin structure have these receptors become amenable to a rational drug design. Based on recent examples from academia and the pharmaceutical industry, this book demonstrates how to apply the whole range of bioinformatics, chemoinformatics and molecular modeling tools to the rational design of novel drugs targeting GPCRs. Essential reading for medicinal chemists and drug designers working with this largest class of drug targets in the human genome.

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