Sepsis: New Strategies for Management

Description

Sepsis is an important public health problem around the world. Severe sepsis carries significant morbidity, mortality and high costs. The incidence of sepsis is increasing because of the aging population, the growing number of immunocompromised hosts, the increasing use of invasive procedures, and, to a lesser extent, antibiotic resistance among pathogens. Despite recent advances in the pathogenesis, diagnosis, and therapeutic approaches the mortality rate associated with this condition remains high. Therefore, the goal of Sepsis: New Strategies is to review novel targets to be considered in patients with severe sepsis and to assess new developments for patients with sepsis originating in the respiratory tract. Front Matter....Pages i-xi Macrolides in Severe Community-Acquired Pneumonia and Sepsis....Pages 1-17 The Potential Role of Statins in Severe Sepsis....Pages 19-28 The Genetics of Sepsis: The Promise, the Progress and the Pitfalls....Pages 29-43 Corticoids in Severe Pneumonia....Pages 45-51 Aging, Inflammation, and Pneumococcal Disease....Pages 53-68 Nonspecific Removal of Sepsis Mediators....Pages 69-84 Optimal Antibiotic Use in Severe Community-Acquired Pneumonia....Pages 85-95 Dose Adjustment and Pharmacodynamic Considerations for Antibiotics in Severe Sepsis and Septic Shock....Pages 97-136 Back Matter....Pages 137-142